| Maternal caffeine consumption and risk of cardiovascular malformations. | |
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MedLine Citation:
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PMID: 17405163 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The physiologic effects and common use of caffeine during pregnancy call for examination of maternal caffeine consumption and risk of birth defects. Epidemiologic studies have yielded mixed results, but such studies have grouped etiologically different defects and have not evaluated effect modification. METHODS: The large sample size and precise case classification of the National Birth Defects Prevention Study allowed us to examine caffeine consumption and specific cardiovascular malformation (CVM) case groups. We studied consumption of caffeinated coffee, tea, soda, and chocolate to estimate total caffeine intake and separately examined exposure to each caffeinated beverage. Smoking, alcohol, vasoactive medications, folic acid supplement use, and infant gender were evaluated for effect modification. Maternal interview reports for 4,196 CVM case infants overall and 3,957 control infants were analyzed. RESULTS: We did not identify any significant positive associations between maternal caffeine consumption and CVMs. For tetralogy of Fallot, nonsignificant elevations in risk were observed for moderate (but not high) caffeine intake overall and among nonsmokers (ORs of 1.3 to 1.5). Risk estimates for both smoking and consuming caffeine were less than the sum of the excess risks for each exposure. We observed an inverse trend between coffee intake and risk of atrial septal defect; however, this single significant pattern of association might have been a chance finding. CONCLUSIONS: Our study found no evidence for an appreciable teratogenic effect of caffeine with regard to CVMs. |
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Authors:
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Marilyn L Browne; Erin M Bell; Charlotte M Druschel; Lenore J Gensburg; Allen A Mitchell; Angela E Lin; Paul A Romitti; Adolfo Correa; |
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Publication Detail:
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Type: Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Birth defects research. Part A, Clinical and molecular teratology Volume: 79 ISSN: 1542-0752 ISO Abbreviation: Birth Defects Res. Part A Clin. Mol. Teratol. Publication Date: 2007 Jul |
Date Detail:
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Created Date: 2007-07-16 Completed Date: 2007-10-02 Revised Date: 2007-12-03 |
Medline Journal Info:
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Nlm Unique ID: 101155107 Medline TA: Birth Defects Res A Clin Mol Teratol Country: United States |
Other Details:
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Languages: eng Pagination: 533-43 Citation Subset: IM |
Copyright Information:
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(c) 2007 Wiley-Liss, Inc. |
Affiliation:
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Bureau of Environmental & Occupational Epidemiology, New York State Department of Health, Troy, New York, USA. mlb10@health.state.ny.us |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Caffeine / administration & dosage* Cardiovascular Abnormalities / epidemiology* Case-Control Studies Central Nervous System Stimulants / administration & dosage* Child Female Humans Infant, Newborn Pregnancy Risk Assessment United States / epidemiology |
| Grant Support | |
ID/Acronym/Agency:
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U50/CCU0223184//PHS HHS |
| Chemical | |
Reg. No./Substance:
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0/Central Nervous System Stimulants; 58-08-2/Caffeine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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