| Maternal breast-milk and intestinal bifidobacteria guide the compositional development of the Bifidobacterium microbiota in infants at risk of allergic disease. | |
| | |
MedLine Citation:
|
PMID: 17941914 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: The sources and the impact of maternal bacteria on the initial inoculum of the intestinal microflora of newborn infants remain elusive. OBJECTIVE: To assess the association between maternal breast-milk and fecal bifidobacteria and infants' fecal bifidobacteria. METHODS: Sixty-one mother-infant pairs were included, special emphasis being placed on the maternal allergic status. Bifidobacteria were analysed by a direct PCR method in fecal samples from mothers at 30-35 weeks of gestation and from infants at 1 month of age and from breast-milk samples 1 month post-partum. RESULTS: Fecal Bifidobacterium adolescentis and Bifidobacterium bifidum colonization frequencies and counts among mother-infant pairs correlated significantly (P=0.005 and 0.02 for frequencies, respectively, and P=0.002 and 0.01 for counts, respectively). Only infants of allergic, atopic mothers were colonized with B. adolescentis. Each of the breast-milk samples contained bifidobacteria [median 1.4 x 10(3) bacterial cells/mL; interquartile range (IQR) 48.7-3.8 x 10(3)]. Bifidobacterium longum was the most frequently detected species in breast-milk. Allergic mothers had significantly lower amounts of bifidobacteria in breast-milk compared with non-allergic mothers [median 1.3 x 10(3) bacterial cells/mL (IQR 22.4-3.0 x 10(3)) vs. 5.6 x 10(3) bacterial cells/mL (1.8 x 10(3)-1.8 x 10(4)), respectively, (P=0.004)], and their infants had concurrently lower counts of bifidobacteria in feces [3.9 x 10(8) bacterial cells/g (IQR 6.5 x 10(6)-1.5 x 10(9)) in infants of allergic mothers, vs. 2.5 x 10(9) bacterial cells/g (6.5 x 10(8)-3.2 x 10(10)) in infants of non-allergic mothers, P=0.013]. CONCLUSIONS: Breast-milk contains significant numbers of bifidobacteria and the maternal allergic status further deranges the counts of bifidobacteria in breast-milk. Maternal fecal and breast-milk bifidobacterial counts impacted on the infants' fecal Bifidobacterium levels. Breast-milk bacteria should thus be considered an important source of bacteria in the establishment of infantile intestinal microbiota. |
| | |
Authors:
|
M-M Grönlund; M Gueimonde; K Laitinen; G Kociubinski; T Grönroos; S Salminen; E Isolauri |
Related Documents
:
|
14575224 - Neonatal hypernatraemic dehydration and malnutrition associated with inadequate breastf... 7773894 - Nutrient needs and feeding of premature infants. nutrition committee, canadian paediatr... 11065074 - Subclinical mastitis as a risk factor for mother-infant hiv transmission. 15673654 - Sharing the science on human milk feedings with mothers of very-low-birth-weight infants. 14575224 - Neonatal hypernatraemic dehydration and malnutrition associated with inadequate breastf... 7773894 - Nutrient needs and feeding of premature infants. nutrition committee, canadian paediatr... |
Publication Detail:
|
Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2007-10-16 |
Journal Detail:
|
Title: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology Volume: 37 ISSN: 1365-2222 ISO Abbreviation: Clin. Exp. Allergy Publication Date: 2007 Dec |
Date Detail:
|
Created Date: 2007-11-21 Completed Date: 2008-10-06 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8906443 Medline TA: Clin Exp Allergy Country: England |
Other Details:
|
Languages: eng Pagination: 1764-72 Citation Subset: IM |
Affiliation:
|
Department of Pediatrics, Turku University Central Hospital, Turku, Finland. mingro@utu.fi |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Bifidobacteriales Infections
/
microbiology,
transmission Bifidobacterium / physiology* Feces / microbiology Female Humans Hypersensitivity / immunology, microbiology* Infant Infant, Newborn Intestines / microbiology* Milk, Human / microbiology* Mothers* Risk Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Neurokinin-1 receptor activation induces reactive oxygen species and epithelial damage in allergic a...
Next Document: Atopic features of cough variant asthma and classic asthma with wheezing.