| Maternal body mass index and serum concentrations of human chorionic gonadotropin in very early pregnancy. | |
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MedLine Citation:
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PMID: 22769733 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE: To study the association of maternal prepregnancy body mass index (BMI) with serum concentrations of hCG in early pregnancy. DESIGN: Cross-sectional study. SETTING: Oslo University Hospital, Norway, 1996-2010. PATIENT(S): Among 3,301 pregnancies with live-born offspring conceived after assisted reproductive techniques, 2,611 women had information on serum hCG concentrations on day 16 after ovulation induction and prepregnancy BMI: 2,110 mothers with singleton and 501 mothers with multiple pregnancy. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Human chorionic gonadotropin concentration. RESULT(S): Geometric mean hCG concentration was higher in multiple pregnancies (190 IU/L) than in singleton pregnancies (106 IU/L). In singleton pregnancies geometric mean serum concentration decreased from 117 IU/L in women with BMI <20 kg/m(2) to 86 IU/L in women with BMI ≥35 kg/m(2). In multiple pregnancies, the corresponding decrease was from 226 IU/L to 130 IU/L. There was a significant negative association of BMI with hCG concentrations log transformed in the study sample as a whole (regression coefficient -0.013), in singleton pregnancies (regression coefficient -0.012), and in multiple pregnancies (regression coefficient -0.03). CONCLUSION(S): Serum hCG concentrations were negatively associated with maternal prepregnancy BMI. One possible explanation may be an effect of adipose tissue-derived signaling molecules on hCG secretion by the implanting embryo. |
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Authors:
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Anne Eskild; Peter Fedorcsak; Lars Mørkrid; Tom G Tanbo |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-7-4 |
Journal Detail:
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Title: Fertility and sterility Volume: - ISSN: 1556-5653 ISO Abbreviation: - Publication Date: 2012 Jul |
Date Detail:
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Created Date: 2012-7-9 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Obstetrics and Gynecology and Institute of Clinical Medicine, Akershus University Hospital, Lørenskog, Norway; Department of Mental Health, Norwegian Institute of Public Health, Oslo, Norway. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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