Document Detail

Maternal blood volume in placenta of the rhesus monkey measured in vivo by positron emission tomography.
MedLine Citation:
PMID:  2010109     Owner:  NLM     Status:  MEDLINE    
The relative volume of the intervillous space of the placenta of the rhesus monkey was measured in vivo using positron emission tomography (PET), a noninvasive tracer technique. 11CO-Hb and 68GaCl3 were both used in three experiments and 68Ga-EDTA in two. The tracers were administered intravenously as bolus doses to 6 pregnant monkeys during 7 different pregnancies. Measurements with 11CO-Hb gave a volume of 48.0% of the total placental volume. Transplacental transfer of 11CO to the fetal circulation is probably a minor problem due to the small fetal blood volume and the prolonged time before the same concentration is reached in the maternal and fetal blood. Measurements with 68GaCl3, which binds to transferrin, gave an intervillous space volume of 55.6% of the placental volume. The concentration of radioactivity in the placenta did not attain a steady state, indicating a clearance of the tracer from the blood only to a small extent. Measurements with 68Ga-EDTA displayed a volume of 60.4% of the placental volume. Transplacental transfer and the additional distribution of radioactivity to fetal and maternal extracellular spaces, including the placenta, when 68Ga-EDTA was used will make this tracer unsuitable in measurements of the blood volume of the placenta with PET.
L Berglund; A Lilja; J Andersson; B Lindberg; J Ulin; B Långström; H Lundqvist
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Gynecologic and obstetric investigation     Volume:  31     ISSN:  0378-7346     ISO Abbreviation:  Gynecol. Obstet. Invest.     Publication Date:  1991  
Date Detail:
Created Date:  1991-05-09     Completed Date:  1991-05-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7900587     Medline TA:  Gynecol Obstet Invest     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  1-7     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Akademiska Sjukhuset, Uppsala, Sweden.
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MeSH Terms
Blood Volume / physiology
Blood Volume Determination / methods
Carbon Radioisotopes / diagnostic use
Fetal Blood / physiology
Gallium Radioisotopes / diagnostic use
Macaca mulatta
Placenta / blood supply*,  radionuclide imaging
Pregnancy, Animal / physiology*
Tomography, Emission-Computed*
Reg. No./Substance:
0/Carbon Radioisotopes; 0/Gallium Radioisotopes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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