Document Detail


Maternal betamethasone and fetal growth and development in the monkey.
MedLine Citation:
PMID:  402074     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Bethamethasone was administered to pregnant rhesus monkeys of 134 to 150 days' gestation. At operative delivery, umbilical venous plasma cortisol concentrations were significantly lower in the treated group than in the control group, indicating that the agent crossed the placenta. In the treated group, accelerated differentiation was present in several fetal organs including lung, liver, kidney, and adrenal gland. Brain histologic changes suggestive of neuronal injury were found in some instances. There were no differences in the weights of these fetal organs except for liver. It was markedly increased in steroid-treated fetuses and this was accompanied by a fourfold rise in total hepatic glycogen content. These observations suggest that in the subhuman fetal primate, the differentiation of fetal organs in addition to lung is enhanced by short-term corticosteroid treatment while growth is not affected.
Authors:
M F Epstein; P M Farrell; J W Sparks; G Pepe; S G Driscoll; R A Chez
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  127     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1977 Feb 
Date Detail:
Created Date:  1977-03-15     Completed Date:  1977-03-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  261-3     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Betamethasone / pharmacology*
Female
Fetus / drug effects*,  physiology
Glycogen / analysis
Growth
Haplorhini
Hydrocortisone / blood
Liver / analysis
Macaca mulatta
Maternal-Fetal Exchange
Organ Size / drug effects
Pregnancy
Chemical
Reg. No./Substance:
378-44-9/Betamethasone; 50-23-7/Hydrocortisone; 9005-79-2/Glycogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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