Document Detail

Maternal behavior in a genetic animal model of absence epilepsy.
MedLine Citation:
PMID:  19112473     Owner:  NLM     Status:  MEDLINE    
In this study we quantified maternal behavior in genetic epileptic rats with deficiencies in the DA system known to be involved in maternal behavior in order to assess whether these rats have disturbances in maternal care. Wistar Albino Glaxo/Rijswijk (WAG/Rij) rats, a genetic model for generalized absence epilepsy and Wistar rats were compared. Maternal behavior parameters and activity scores were quantified from post-natal day (PND) 4-6 in an open field in the presence of pups. WAG/Rij rats had less approaches to the pups and higher latencies of approaching them compared to Wistar, while locomotion showed a different pattern over days. This confirms the hypothesis that animals with absence epilepsy show more poor maternal behavior and that these effects cannot be solely attributed to differences in locomotor activity. It is proposed that the reduction in maternal care is attributed to low activity in the mesolimbic DA system.
Yulia V Dobryakova; Vyacheslav A Dubynin; Gilles van Luijtelaar
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta neurobiologiae experimentalis     Volume:  68     ISSN:  0065-1400     ISO Abbreviation:  Acta Neurobiol Exp (Wars)     Publication Date:  2008  
Date Detail:
Created Date:  2008-12-29     Completed Date:  2009-03-13     Revised Date:  2014-03-25    
Medline Journal Info:
Nlm Unique ID:  1246675     Medline TA:  Acta Neurobiol Exp (Wars)     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  502-8     Citation Subset:  IM    
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MeSH Terms
Analysis of Variance
Brain Chemistry / genetics,  physiology
Epilepsy, Absence / genetics*,  psychology*
Maternal Behavior / psychology*
Rats, Wistar
Receptors, Dopamine / genetics,  physiology
Reg. No./Substance:
0/Receptors, Dopamine

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