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Maternal autoimmune thyroiditis and congenital malformations of newborns in a cohort of Slovak women.
MedLine Citation:
PMID:  20737223     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
BACKGROUND: Aim of this study was to compare the thyroidal status of mothers to children with and without congenital malformations (CM).
METHODS: We examined 129 mothers of newborns with CM and 228 mothers without CM. The assessment included particular history, physical examination, thyroid ultrasonography, fT4, TSH, and anti-TPO measurement of mothers and comparison to birth proportions of newborns.
RESULTS: The total volume of the thyroid gland and anti-TPO levels were significantly higher in mothers of the group with CM (p < 0.001 and p < 0.01, respectively). The birth weight and length were significantly lower in the group with congenital malformation when compared to controls (p < 0.0001 and p < 0.001, respectively).
CONCLUSIONS: Based on the results of our study, we suggest that thyroid diseases of a mother might participate in congenital malformations of their newborn, although no direct association between thyroid autoantibodies and congenital malformations has been described as of yet.
Authors:
Viola Vargová; Marek Pytliak; Viola Mechírová; Marek Felšöci
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Publication Detail:
Type:  Journal Article     Date:  2010-08-24
Journal Detail:
Title:  Wiener medizinische Wochenschrift (1946)     Volume:  160     ISSN:  1563-258X     ISO Abbreviation:  Wien Med Wochenschr     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-10-06     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8708475     Medline TA:  Wien Med Wochenschr     Country:  Austria    
Other Details:
Languages:  eng     Pagination:  470-4     Citation Subset:  IM    
Affiliation:
Pavol Jozef Šafárik University, Košice, Slovak Republic.
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