Document Detail

Maternal autoimmune diseases, asthma and allergies, and childhood autism spectrum disorders: a case-control study.
MedLine Citation:
PMID:  15699309     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate the association between physician-documented diagnoses of maternal autoimmune diseases, allergies, and asthma around the time of pregnancy and subsequent diagnoses of autism in children. DESIGN: A case-control study nested within a cohort of infants born between January 1995 and June 1999. SETTING: Northern California Kaiser Permanente Medical Care Program. PARTICIPANTS: Cases (n = 420) were children with at least 1 diagnosis of an autism spectrum disorder (ASD) recorded in Kaiser Permanente outpatient clinical databases. Controls (n = 2100) were children without an ASD diagnosis who were frequency matched to cases on sex, birth year, and hospital of birth. MAIN OUTCOME MEASURES: Frequencies of maternal immunologic disorders were compared between cases and controls with a chi2 statistic, and relative risks were estimated by crude and adjusted odds ratios and 95% confidence intervals using logistic regression. RESULTS: The final study population included 407 cases and 2095 controls. A similar proportion of case and control mothers had a diagnosis of any autoimmune disease in the 4-year period surrounding pregnancy (10.3% vs 8.2%, P = .15). After adjustment for maternal factors, only 1 autoimmune condition, psoriasis, was significantly associated with ASDs (adjusted odds ratio, 2.7; 95% confidence interval, 1.3-5.8). A greater than 2-fold elevated risk of ASD was observed for maternal asthma and allergy diagnoses recorded during the second trimester of pregnancy. CONCLUSIONS: These findings suggest that maternal autoimmune disorders present in women around the time of pregnancy are unlikely to contribute significantly to autism risk. Further etiologic investigations are needed to confirm these results and should include objective documentation of diagnoses and consider a larger set of maternal immune-related conditions, including asthma and allergies.
Lisa A Croen; Judith K Grether; Cathleen K Yoshida; Roxana Odouli; Judy Van de Water
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Archives of pediatrics & adolescent medicine     Volume:  159     ISSN:  1072-4710     ISO Abbreviation:  Arch Pediatr Adolesc Med     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-02-08     Completed Date:  2005-02-25     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9422751     Medline TA:  Arch Pediatr Adolesc Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  151-7     Citation Subset:  AIM; IM    
Division of Research, Kaiser Foundation Research Institute, Kaiser Permanente, Oakland, Calif. 94612, USA.
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MeSH Terms
Asthma / epidemiology,  immunology*
Autistic Disorder / diagnosis*,  etiology,  immunology
Autoimmune Diseases / epidemiology,  immunology*
Case-Control Studies
Child, Preschool
Hypersensitivity / epidemiology,  immunology*
Logistic Models
Pregnancy Complications / epidemiology,  immunology*
Time Factors
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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