Document Detail

Maternal atopic disease modifies effects of prenatal risk factors on exhaled nitric oxide in infants.
MedLine Citation:
PMID:  15059789     Owner:  NLM     Status:  MEDLINE    
In a prospective healthy birth cohort, we determined whether levels of exhaled nitric oxide (eNO) in healthy unselected infants at the age of 1 month were associated with maternal atopic disease and prenatal and early postnatal environmental exposures. Tidal eNO was measured in 98 healthy, unsedated infants (35 from mothers with atopy) (mean age +/- SD, 36.0 +/- 6.2 days) and was compared with histories taken in standardized interviews. eNO was higher in males compared with females (17.7 vs. 14.6 ppb, p = 0.042) and infants exposed to postnatal maternal smoking (+4.4 ppb, p = 0.027), adjusting for weight and tidal breathing parameters. Prenatal tobacco exposure was associated with higher eNO (+12.0 ppb, p = 0.01) in infants of mothers with asthma and lower eNO (-5.7 ppb) in infants of mothers without asthma (p for interaction < 0.0001). Coffee consumption in pregnancy decreased eNO (-6.0 ppb, p = 0.008) only in children of mothers with atopy (p for interaction = 0.015). Paternal atopy had no influence. In the early phase of immunologic development, before the onset of infections and allergic disease, the effect of prenatal or early postnatal environmental factors on eNO was modified by the presence of maternal atopic disease. This underlines the complex interaction of maternal and environmental factors in the development of airway disease.
Urs Frey; Claudia Kuehni; Hanna Roiha; Mateja Cernelc; Benjamin Reinmann; Johannes H Wildhaber; Graham L Hall
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2004-04-01
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  170     ISSN:  1073-449X     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-07-28     Completed Date:  2004-09-02     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  260-5     Citation Subset:  AIM; IM    
Swiss Pediatric Respiratory Research Group, Department of Pediatrics, University Hospital of Zurich, Switzerland.
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MeSH Terms
Asthma / epidemiology*,  metabolism
Breath Tests*
Cohort Studies
Environmental Exposure / statistics & numerical data*
Hypersensitivity / epidemiology*
Infant, Newborn
Nitric Oxide / analysis*
Prenatal Exposure Delayed Effects*
Prospective Studies
Respiratory Function Tests
Risk Factors
Sex Distribution
Smoking / epidemiology
Switzerland / epidemiology
Reg. No./Substance:
0/Coffee; 10102-43-9/Nitric Oxide; 58-08-2/Caffeine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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