Document Detail

Maternal asthma, its control and severity in pregnancy, and the incidence of atopic dermatitis and allergic rhinitis in the offspring.
MedLine Citation:
PMID:  19616789     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the relationship between maternal asthma, its level of control and severity during pregnancy, and atopic dermatitis (AD) and allergic rhinitis (AR) incidence in children. STUDY DESIGN: A cohort of 26 265 singletons born to mothers with and without asthma (1990-2002) was constituted by use of 3 Quebec databases. Mothers with asthma had to have received >or=1 diagnosis and >or=1 prescription for asthma 2 years before or during pregnancy. Asthma control and severity during pregnancy was based on validated indexes. ICD-9 codes 691 and 477 allowed us to identify cases of AD and AR. RESULTS: Maternal asthma during pregnancy was associated with an increased AD risk (adjusted hazard ratio: 1.11, 95% confidence interval: 1.02-1.21), but not of AR (adjusted hazard ratio: 1.04, 95% confidence interval: 0.91-1.20) in children. Asthma control and severity were not associated with either outcome. Maternal AR and intranasal corticosteroid use during pregnancy increased the risk of childhood AR by 70% and 45%. CONCLUSIONS: Children of mothers with asthma or AR during pregnancy should be closely monitored to diagnose and treat AD and AR as early as possible.
Marie-Josée Martel; Marie-France Beauchesne; Jean-Luc Malo; Evelyne Rey; Sylvie Perreault; Amélie Forget; Lucie Blais
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-07-19
Journal Detail:
Title:  The Journal of pediatrics     Volume:  155     ISSN:  1097-6833     ISO Abbreviation:  J. Pediatr.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-10-20     Completed Date:  2009-12-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  707-13.e1     Citation Subset:  AIM; IM    
Faculty of Pharmacy, Université de Montréal, Montréal, Québec, Canada.
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MeSH Terms
Age Distribution
Anti-Asthmatic Agents / therapeutic use
Asthma / diagnosis,  drug therapy,  immunology*
Cohort Studies
Confidence Intervals
Dermatitis, Atopic / diagnosis,  epidemiology,  immunology*
Follow-Up Studies
Infant, Newborn
International Classification of Diseases
Multivariate Analysis
Pregnancy Complications / diagnosis,  drug therapy,  immunology*
Proportional Hazards Models
Quebec / epidemiology
Retrospective Studies
Rhinitis, Allergic, Perennial / diagnosis,  epidemiology,  immunology*
Severity of Illness Index
Sex Distribution
Grant Support
//Canadian Institutes of Health Research
Reg. No./Substance:
0/Anti-Asthmatic Agents

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