| Maternal arterial stiffness in pregnancies complicated by gestational and type 2 diabetes mellitus. | |
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MedLine Citation:
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PMID: 20659727 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: We sought to investigate whether maternal arterial stiffness is altered in pregnant women with gestational diabetes mellitus (GDM) and type 2 diabetes compared to normoglycemic women. STUDY DESIGN: We conducted a cross-sectional study involving 34 women with GDM and their controls (n = 34), and 34 women with type 2 diabetes and their controls (n = 34). Maternal arterial stiffness was assessed using applanation tonometry. RESULTS: In patients with GDM, compared to their controls, augmentation index (a measure of arterial wave reflection) was higher (13.1 +/- 8.9% vs 0.7 +/- 11.4%; P < .001) and pulse wave velocity (PWV) (arterial stiffness of the carotid-femoral) was marginally increased (6 +/- 1.5 vs 5.4 +/- 0.6 m/s; P = .07). In type 2 diabetics, compared to their controls, both augmentation index and PWV were increased (11.5 +/- 11.4% vs 3.3 +/- 12.5%; P = .006, and 6.8 +/- 1.2 vs 5.6 +/- 1 m/s; P < .001). When all groups were considered together, there was a significant trend of increasing augmentation index (P = .001) and PWV (P < .001) from controls to those with GDM to type 2 diabetes. CONCLUSION: Pregnancies complicated by GDM and type 2 diabetes are associated with increased maternal arterial stiffness. |
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Authors:
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Makrina D Savvidou; James M Anderson; Christine Kaihura; Kypros H Nicolaides |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-07-24 |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 203 ISSN: 1097-6868 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-06 Completed Date: 2010-09-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 274.e1-7 Citation Subset: AIM; IM |
Copyright Information:
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Copyright 2010 Mosby, Inc. All rights reserved. |
Affiliation:
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Department of Maternal-Fetal Medicine, Imperial College School of Medicine, Chelsea and Westminster Hospital, London, UK. msavvidou@dsla.ndo.co.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Arteries / physiopathology* Blood Flow Velocity / physiology Blood Pressure / physiology Case-Control Studies Cross-Sectional Studies Diabetes Mellitus, Type 2 / physiopathology* Diabetes, Gestational / physiopathology* Female Heart Rate / physiology Humans Linear Models Manometry Maternal Age Pregnancy Pregnancy in Diabetics / physiopathology* Pulsatile Flow / physiology |
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