| Maternal arterial connections to the placental intervillous space during the first trimester of human pregnancy: the Boyd collection revisited. | |
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MedLine Citation:
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PMID: 10486489 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: We sought to determine morphologically when the maternal uterine circulation to the human placenta is established. STUDY DESIGN: We performed a histologic review of 12 early-pregnancy hysterectomy specimens contained within the Boyd Collection, ranging from 43 to 130 days' gestation. RESULTS: Before the eighth week of pregnancy, maternal arterial connections with the intervillous space are restricted to tortuous networks of intercellular spaces. Only after this period can direct channels be observed. Initially, these are of small caliber, but they become sizable and clearly delineated after 11 to 12 weeks. CONCLUSION: The maternal circulation to the placenta must be extremely sluggish before the eighth week of pregnancy but will be gradually established over the next few weeks. It is unlikely to be substantial until at least 12 weeks. The implication is that development of the human fetoplacental unit during most of the first trimester takes place in a low-oxygen environment. |
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Authors:
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G J Burton; E Jauniaux; A L Watson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 181 ISSN: 0002-9378 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 1999 Sep |
Date Detail:
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Created Date: 1999-10-07 Completed Date: 1999-10-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 718-24 Citation Subset: AIM; IM |
Affiliation:
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Department of Anatomy, University of Cambridge, London, United Kingdom. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Arteries
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anatomy & histology* Crown-Rump Length Endothelium, Vascular / anatomy & histology Female Gestational Age* Humans Placenta / blood supply* Pregnancy Pregnancy Trimester, First Trophoblasts |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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