| Maternal antimullerian hormone levels do not predict fetal aneuploidy. | |
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MedLine Citation:
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PMID: 20490648 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To determine if diminished ovarian reserve (measured by maternal antimullerian hormone (AMH) levels), is associated with fetal aneuploidy (determined by prenatal karyotype). METHODS: This case-control study included 213 women with singleton pregnancies who underwent both serum aneuploidy screening and invasive prenatal diagnosis. 18 patients carrying an aneuploid fetus served as cases and the remaining 195 women with a euploid fetus were controls. Serum AMH was measured using two assays: AMHbc (Beckman-Coulter) and AMHdsl (Diagnostic Systems Laboratories). Karyotypes were determined by chorionic villus sampling or amniocentesis. RESULTS: AMHbc levels did not differ between women with an aneuploid fetus and women with a euploid fetus (p = 0.46) and did not predict aneuploidy (ROC Area = 0.57). Additionally, AMHbc values declined significantly with advancing gestational age. CONCLUSIONS: Maternal AMH does not appear to be a marker of fetal aneuploidy in ongoing pregnancies. Contrary to previous reports, we found a significant decline in maternal AMH levels with advancing gestational age. |
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Authors:
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Beth J Plante; Carmen Beamon; Colleen L Schmitt; Julie S Moldenhauer; Anne Z Steiner |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-05-20 |
Journal Detail:
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Title: Journal of assisted reproduction and genetics Volume: 27 ISSN: 1573-7330 ISO Abbreviation: J. Assist. Reprod. Genet. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-08-13 Completed Date: 2011-02-17 Revised Date: 2011-08-01 |
Medline Journal Info:
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Nlm Unique ID: 9206495 Medline TA: J Assist Reprod Genet Country: Netherlands |
Other Details:
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Languages: eng Pagination: 409-14 Citation Subset: IM |
Affiliation:
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The University of North Carolina School of Medicine, Department of Obstetrics and Gynecology, Chapel Hill, 27599-7570, USA. bethplante@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aneuploidy* Anti-Mullerian Hormone / blood* Case-Control Studies Chorionic Villi Sampling Female Gestational Age Humans Pregnancy |
| Grant Support | |
ID/Acronym/Agency:
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5K12HD050113/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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80497-65-0/Anti-Mullerian Hormone |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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