Document Detail


Maternal antimullerian hormone levels do not predict fetal aneuploidy.
MedLine Citation:
PMID:  20490648     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To determine if diminished ovarian reserve (measured by maternal antimullerian hormone (AMH) levels), is associated with fetal aneuploidy (determined by prenatal karyotype).
METHODS: This case-control study included 213 women with singleton pregnancies who underwent both serum aneuploidy screening and invasive prenatal diagnosis. 18 patients carrying an aneuploid fetus served as cases and the remaining 195 women with a euploid fetus were controls. Serum AMH was measured using two assays: AMHbc (Beckman-Coulter) and AMHdsl (Diagnostic Systems Laboratories). Karyotypes were determined by chorionic villus sampling or amniocentesis.
RESULTS: AMHbc levels did not differ between women with an aneuploid fetus and women with a euploid fetus (p = 0.46) and did not predict aneuploidy (ROC Area = 0.57). Additionally, AMHbc values declined significantly with advancing gestational age.
CONCLUSIONS: Maternal AMH does not appear to be a marker of fetal aneuploidy in ongoing pregnancies. Contrary to previous reports, we found a significant decline in maternal AMH levels with advancing gestational age.
Authors:
Beth J Plante; Carmen Beamon; Colleen L Schmitt; Julie S Moldenhauer; Anne Z Steiner
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-05-20
Journal Detail:
Title:  Journal of assisted reproduction and genetics     Volume:  27     ISSN:  1573-7330     ISO Abbreviation:  J. Assist. Reprod. Genet.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-08-13     Completed Date:  2011-02-17     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  9206495     Medline TA:  J Assist Reprod Genet     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  409-14     Citation Subset:  IM    
Affiliation:
The University of North Carolina School of Medicine, Department of Obstetrics and Gynecology, Chapel Hill, 27599-7570, USA. bethplante@gmail.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Aneuploidy*
Anti-Mullerian Hormone / blood*
Case-Control Studies
Chorionic Villi Sampling
Female
Gestational Age
Humans
Pregnancy
Grant Support
ID/Acronym/Agency:
5K12HD050113/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
80497-65-0/Anti-Mullerian Hormone
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