Document Detail

Maternal antimullerian hormone levels do not predict fetal aneuploidy.
MedLine Citation:
PMID:  20490648     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To determine if diminished ovarian reserve (measured by maternal antimullerian hormone (AMH) levels), is associated with fetal aneuploidy (determined by prenatal karyotype).
METHODS: This case-control study included 213 women with singleton pregnancies who underwent both serum aneuploidy screening and invasive prenatal diagnosis. 18 patients carrying an aneuploid fetus served as cases and the remaining 195 women with a euploid fetus were controls. Serum AMH was measured using two assays: AMHbc (Beckman-Coulter) and AMHdsl (Diagnostic Systems Laboratories). Karyotypes were determined by chorionic villus sampling or amniocentesis.
RESULTS: AMHbc levels did not differ between women with an aneuploid fetus and women with a euploid fetus (p = 0.46) and did not predict aneuploidy (ROC Area = 0.57). Additionally, AMHbc values declined significantly with advancing gestational age.
CONCLUSIONS: Maternal AMH does not appear to be a marker of fetal aneuploidy in ongoing pregnancies. Contrary to previous reports, we found a significant decline in maternal AMH levels with advancing gestational age.
Beth J Plante; Carmen Beamon; Colleen L Schmitt; Julie S Moldenhauer; Anne Z Steiner
Related Documents :
1086748 - Survey of amniocentesis for fetal sex determination in hemophilia carriers.
12124688 - Outcomes of pregnancies diagnosed with klinefelter syndrome: the possible influence of ...
15292918 - Strategies for the rapid prenatal diagnosis of chromosome aneuploidy.
2798348 - Evaluation of transcervical chorionic villus sampling with a completed follow-up of 155...
10100808 - The east flanders prospective twin survey (belgium): a population-based register.
21680678 - Raltegravir in pregnancy: a case series presentation.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-05-20
Journal Detail:
Title:  Journal of assisted reproduction and genetics     Volume:  27     ISSN:  1573-7330     ISO Abbreviation:  J. Assist. Reprod. Genet.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-08-13     Completed Date:  2011-02-17     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  9206495     Medline TA:  J Assist Reprod Genet     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  409-14     Citation Subset:  IM    
The University of North Carolina School of Medicine, Department of Obstetrics and Gynecology, Chapel Hill, 27599-7570, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Anti-Mullerian Hormone / blood*
Case-Control Studies
Chorionic Villi Sampling
Gestational Age
Grant Support
Reg. No./Substance:
80497-65-0/Anti-Mullerian Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Tea consumption and risk of ovarian cancer.
Next Document:  Birth of a healthy infant following preimplantation PKHD1 haplotyping for autosomal recessive polycy...