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Maternal antihypertensive drugs may influence cerebral oxygen extraction in preterm infants during the first days after birth.
MedLine Citation:
PMID:  23330812     Owner:  NLM     Status:  Publisher    
Abstract Objective To determine whether maternal antihypertensive drugs influenced cerebral oxygenation in preterm infants during the first days after birth. Methods We included 49 preterm infants (median gestational age 30.3 weeks, (range 26.0-31.9), birth weight 1250 grams, (560-2250)). Regional cerebral oxygen saturation (r(c)SO(2)) was measured by near-infrared spectroscopy on postnatal days 1,2,3,4,5. Fractional tissue oxygen extraction (FTOE) was calculated using r(c)SO(2) and arterial oxygen saturation (SpO(2)) values:(SpO(2)-r(c)SO(2))/SpO(2). Results Nine mothers were treated with labetalol and/or MgSO(4) during pregnancy, three mothers with labetalol, MgSO(4), and nifedipine, and 19 mothers with nifedipine only. Eighteen infants served as controls. Multivariate linear regression analysis showed that exposure to labetalol and/or MgSO(4) during pregnancy decreased FTOE on day 1 after birth, while nifedipine did not. Conclusions Treating pregnant women with labetalol and/or MgSO(4) may influence cerebral oxygen extraction in their offspring shortly after birth.
Elise A Verhagen; Elisabeth M W Kooi; Paul P van den Berg; Arend F Bos
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-18
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  -     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
.Division of Neonatology, Beatrix Children's Hospital, University of Groningen, University Medical Center Groningen, the Netherlands.
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