Document Detail


Maternal antibodies to pneumolysin but not to pneumococcal surface protein A delay early pneumococcal carriage in high-risk Papua New Guinean infants.
MedLine Citation:
PMID:  19776196     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Immunization of pregnant women can be an efficient strategy to induce early protection in infants in developing countries. Pneumococcal protein-based vaccines may have the capacity to induce pneumococcal serotype-independent protection. To understand the potential of maternal pneumococcal protein-specific antibodies in infants in high-risk areas, we studied the placental transfer of naturally acquired antibodies to pneumolysin (Ply) and pneumococcal surface protein A family 1 and 2 (PspA1 and PspA2) in relation to onset of pneumococcal nasopharyngeal carriage in infants in Papua New Guinea (PNG). In this study, 76% of the infants carried Streptococcus pneumoniae in the upper respiratory tract within the first month of life, at a median age of 19 days. Maternal and cord blood antibody titers to Ply (rho = 0.824, P < 0.001), PspA1 (rho = 0.746, P < 0.001), and PspA2 (rho = 0.631, P < 0.001) were strongly correlated. Maternal pneumococcal carriage (hazard ratio [HR], 2.60; 95% confidence interval [CI], 1.25 to 5.39) and younger maternal age (HR, 0.74; 95% CI, 0.54 to 1.00) were independent risk factors for early carriage, while higher cord Ply-specific antibody titers predicted a significantly delayed onset (HR, 0.71; 95% CI, 0.52 to 1.00) and cord PspA1-specific antibodies a significantly younger onset of carriage in PNG infants (HR, 1.57; 95% CI, 1.03 to 2.40). Maternal vaccination with a pneumococcal protein-based vaccine should be considered as a strategy to protect high-risk infants against pneumococcal disease by reducing carriage risks in both mothers and infants.
Authors:
Jacinta P Francis; Peter C Richmond; William S Pomat; Audrey Michael; Helen Keno; Suparat Phuanukoonnon; Jan B Nelson; Melissa Whinnen; Tatjana Heinrich; Wendy-Anne Smith; Susan L Prescott; Patrick G Holt; Peter M Siba; Deborah Lehmann; Anita H J van den Biggelaar
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-09-23
Journal Detail:
Title:  Clinical and vaccine immunology : CVI     Volume:  16     ISSN:  1556-679X     ISO Abbreviation:  Clin. Vaccine Immunol.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-11-02     Completed Date:  2010-01-07     Revised Date:  2013-05-31    
Medline Journal Info:
Nlm Unique ID:  101252125     Medline TA:  Clin Vaccine Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1633-8     Citation Subset:  IM    
Affiliation:
Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Antibodies, Bacterial / blood*
Bacterial Proteins / immunology*
Carrier State / epidemiology,  immunology,  prevention & control*
Female
Humans
Immunity, Maternally-Acquired*
Infant, Newborn
Nasopharynx / microbiology
Papua New Guinea / epidemiology
Pneumococcal Infections / epidemiology,  immunology,  prevention & control*
Pregnancy
Prevalence
Streptococcus pneumoniae / immunology*,  isolation & purification
Streptolysins / immunology*
Young Adult
Grant Support
ID/Acronym/Agency:
071613/Z/03/Z//Wellcome Trust
Chemical
Reg. No./Substance:
0/Antibodies, Bacterial; 0/Bacterial Proteins; 0/Streptolysins; 0/plY protein, Streptococcus pneumoniae; 0/pneumococcal surface protein A
Comments/Corrections

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