| Maternal antibodies to pneumolysin but not to pneumococcal surface protein A delay early pneumococcal carriage in high-risk Papua New Guinean infants. | |
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MedLine Citation:
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PMID: 19776196 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Immunization of pregnant women can be an efficient strategy to induce early protection in infants in developing countries. Pneumococcal protein-based vaccines may have the capacity to induce pneumococcal serotype-independent protection. To understand the potential of maternal pneumococcal protein-specific antibodies in infants in high-risk areas, we studied the placental transfer of naturally acquired antibodies to pneumolysin (Ply) and pneumococcal surface protein A family 1 and 2 (PspA1 and PspA2) in relation to onset of pneumococcal nasopharyngeal carriage in infants in Papua New Guinea (PNG). In this study, 76% of the infants carried Streptococcus pneumoniae in the upper respiratory tract within the first month of life, at a median age of 19 days. Maternal and cord blood antibody titers to Ply (rho = 0.824, P < 0.001), PspA1 (rho = 0.746, P < 0.001), and PspA2 (rho = 0.631, P < 0.001) were strongly correlated. Maternal pneumococcal carriage (hazard ratio [HR], 2.60; 95% confidence interval [CI], 1.25 to 5.39) and younger maternal age (HR, 0.74; 95% CI, 0.54 to 1.00) were independent risk factors for early carriage, while higher cord Ply-specific antibody titers predicted a significantly delayed onset (HR, 0.71; 95% CI, 0.52 to 1.00) and cord PspA1-specific antibodies a significantly younger onset of carriage in PNG infants (HR, 1.57; 95% CI, 1.03 to 2.40). Maternal vaccination with a pneumococcal protein-based vaccine should be considered as a strategy to protect high-risk infants against pneumococcal disease by reducing carriage risks in both mothers and infants. |
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Authors:
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Jacinta P Francis; Peter C Richmond; William S Pomat; Audrey Michael; Helen Keno; Suparat Phuanukoonnon; Jan B Nelson; Melissa Whinnen; Tatjana Heinrich; Wendy-Anne Smith; Susan L Prescott; Patrick G Holt; Peter M Siba; Deborah Lehmann; Anita H J van den Biggelaar |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-09-23 |
Journal Detail:
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Title: Clinical and vaccine immunology : CVI Volume: 16 ISSN: 1556-679X ISO Abbreviation: Clin. Vaccine Immunol. Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-11-02 Completed Date: 2010-01-07 Revised Date: 2013-05-31 |
Medline Journal Info:
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Nlm Unique ID: 101252125 Medline TA: Clin Vaccine Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 1633-8 Citation Subset: IM |
Affiliation:
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Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Antibodies, Bacterial / blood* Bacterial Proteins / immunology* Carrier State / epidemiology, immunology, prevention & control* Female Humans Immunity, Maternally-Acquired* Infant, Newborn Nasopharynx / microbiology Papua New Guinea / epidemiology Pneumococcal Infections / epidemiology, immunology, prevention & control* Pregnancy Prevalence Streptococcus pneumoniae / immunology*, isolation & purification Streptolysins / immunology* Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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071613/Z/03/Z//Wellcome Trust |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Bacterial; 0/Bacterial Proteins; 0/Streptolysins; 0/plY protein, Streptococcus pneumoniae; 0/pneumococcal surface protein A |
| Comments/Corrections | |
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