Document Detail

Maternal anti-placental cell-mediated reactivity and spontaneous abortions.
MedLine Citation:
PMID:  9228305     Owner:  NLM     Status:  MEDLINE    
PROBLEM: Does Th1/Th2 balance determine pregnancy outcome, and if so, what determines Th1/Th2 balance in pregnancy? METHOD: Review and synthesis of existing data. RESULTS: A bias toward Th1 is strongly correlated with pregnancy failure in mice and humans. Pregnancy usually shifts the balance toward Th2 and placental factors/progesterone and progesterone-stimulated CD8+ T cell production of suppressor factor; TGFbeta2 and IL4/10 may be responsible. The bias toward a Th1 response may result from intracellular parasitic infection and other as yet undefined factors. CONCLUSION: The Th1/Th2 balance thesis appears to be valid.
R Raghupathy
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  American journal of reproductive immunology (New York, N.Y. : 1989)     Volume:  37     ISSN:  1046-7408     ISO Abbreviation:  Am. J. Reprod. Immunol.     Publication Date:  1997 Jun 
Date Detail:
Created Date:  1997-10-09     Completed Date:  1997-10-09     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8912860     Medline TA:  Am J Reprod Immunol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  478-84     Citation Subset:  IM; X    
Department of Microbiology, Faculty of Medicine, Kuwait University.
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MeSH Terms
Abortion, Habitual / immunology
Abortion, Spontaneous / immunology*
Cytokines / secretion
Immunity, Cellular
Lymphocyte Count
Mice, Inbred CBA
Mice, Inbred DBA
Models, Immunological
Placenta / immunology*
Pregnancy / immunology*
Th2 Cells / immunology*,  secretion
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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