Document Detail

Maternal anti-D prophylaxis during pregnancy does not cause neonatal haemolysis.
MedLine Citation:
PMID:  11124929     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate signs of haemolysis in babies of Rh-D negative mothers who underwent prophylaxis with anti-D immunoglobulin during pregnancy. DESIGN: The following were evaluated in all babies of Rh-D negative mothers born within a three month period in our department: haemoglobin level, packed cell volume, mean corpuscular volume, reticulocytes, bilirubin level, and direct Coombs' test (direct anti-globulin test). The babies were divided into two groups according to number of doses of anti-D immunoglobulin received by the mother (one or two), and then further divided by their Rh status (negative or positive). Findings were also compared with a control group of babies of O-Rh positive mothers. RESULTS: The study group consisted of 101 babies and the control group of 37 babies. No statistically significant differences were found for any of the haematological variables between the babies of mothers who received one or two doses of anti-D immunoglobulin, or between the Rh negative babies (n = 35), and the controls. Although 20% of the Rh positive babies born to mothers receiving two doses of anti-D immunoglobulin had a positive result in the direct Coombs' test compared with only 2.4% of the babies of mothers treated with only one dose, no signs of haemolysis were documented in the babies with a positive Coombs test. CONCLUSION: The prevention of Rh isoimmunisation with anti-D immunoglobulin (one or two doses) during pregnancy does not jeopardize the newborn. Blood group typing and direct Coombs' test should be performed in every newborn of an Rh negative mother to establish whether there is a necessity to administer anti-D. In the presence of a positive direct Coombs' test, the type of antibodies should be identified.
A Maayan-Metzger; T Schwartz; J Sulkes; P Merlob
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of disease in childhood. Fetal and neonatal edition     Volume:  84     ISSN:  1359-2998     ISO Abbreviation:  Arch. Dis. Child. Fetal Neonatal Ed.     Publication Date:  2001 Jan 
Date Detail:
Created Date:  2001-01-30     Completed Date:  2001-02-22     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  9501297     Medline TA:  Arch Dis Child Fetal Neonatal Ed     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  F60-2     Citation Subset:  AIM; IM    
Department of Neonatology, Rabin Medical Center, Beilinson Campus, Petah Tiqva, Israel.
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MeSH Terms
Analysis of Variance
Bilirubin / blood
Case-Control Studies
Dose-Response Relationship, Drug
Erythroblastosis, Fetal / blood,  etiology*
Erythrocyte Indices
Hemoglobins / analysis
Infant, Newborn
Pregnancy Complications / drug therapy*
Reticulocytes / chemistry
Rh Isoimmunization / drug therapy*
Rh-Hr Blood-Group System / blood
Rho(D) Immune Globulin / therapeutic use*
Reg. No./Substance:
0/Hemoglobins; 0/Rh-Hr Blood-Group System; 0/Rho(D) Immune Globulin; 635-65-4/Bilirubin

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