Document Detail

Maternal anthropometrics in pregnancy are associated with left ventricular mass in infancy. The generation R study.
MedLine Citation:
PMID:  18043515     Owner:  NLM     Status:  MEDLINE    
Pregnancy and early life factors may permanently affect left ventricular growth and development in the offspring. The aim of this study was to examine the associations of maternal anthropometrics during pregnancy with left ventricular mass (LVM) in infancy. This study was embedded in the Generation R Study, a population-based prospective cohort study from fetal life onwards. Maternal anthropometrics were obtained in early (gestational age <18 wk), mid- (gestational age 18-25 wk), and late (gestational age >25 wk) pregnancy. Echocardiographic follow-up measurements were performed in 791 infants aged 6 wk and 6 mo. We found no associations of maternal height, weight, or body mass index (BMI) measured in early, mid-, and late pregnancy with longitudinally measured left ventricular mass (LVM) from 6 wk to 6 mo. Maternal weight gain until late pregnancy was associated with an increased growth of LVM from 6 wk to 6 mo [difference 0.46 g per week for the highest tertile of weight gain compared with the lowest tertile (p value <0.05)]. We concluded that maternal weight gain until late pregnancy is associated with larger LVM at the age of 6 mo, suggesting that maternal health status during pregnancy may have permanent consequences for LVM in their children. Further studies are needed to identify the underlying causal mechanisms and the long-term consequences.
J J Miranda Geelhoed; Lennie VAN Osch-Gevers; Bero O Verburg; Eric A P Steegers; Albert Hofman; Willem Helbing; Jacqueline C M Witteman; Vincent W V Jaddoe
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric research     Volume:  63     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2007-12-21     Completed Date:  2008-02-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  62-6     Citation Subset:  IM    
The Generation R Study Group, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands.
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MeSH Terms
Birth Weight
Body Height*
Body Mass Index*
Body Weight*
Gestational Age
Health Status
Heart / growth & development*
Heart Ventricles / growth & development,  ultrasonography
Organ Size
Population Surveillance
Prospective Studies
Weight Gain

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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