Document Detail


Maternal antenatal vitamin D status and offspring muscle development: findings from the Southampton Women's Survey.
MedLine Citation:
PMID:  24178796     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CONTEXT: Maternal 25-hydroxyvitamin D [25(OH)D] status in pregnancy has been associated with offspring bone development and adiposity. Vitamin D has also been implicated in postnatal muscle function, but little is known about a role for antenatal 25(OH)D exposure in programming muscle development.
OBJECTIVE: We investigated the associations between maternal plasma 25(OH)D status at 34 weeks of gestation and offspring lean mass and muscle strength at 4 years of age.
DESIGN AND SETTING: We studied a prospective UK population-based mother-offspring cohort: the Southampton Women's Survey (SWS).
PARTICIPANTS: Initially, 12,583 nonpregnant women were recruited into the SWS, of whom 3159 had singleton pregnancies; 678 mother-child pairs were included in this analysis.
MAIN OUTCOMES MEASURED: At 4 years of age, offspring assessments included hand grip strength and whole-body dual-energy x-ray absorptiometry, yielding lean mass and percent lean mass. Physical activity was assessed by 7-day accelerometry in a subset of children (n=326).
RESULTS: The maternal serum 25(OH)D concentration in pregnancy was positively associated with offspring height-adjusted hand grip strength (β=0.10 SD/SD, P=.013), which persisted after adjustment for maternal confounding factors, duration of breastfeeding, and child's physical activity at 4 years (β=0.13 SD/SD, P=.014). Maternal 25(OH)D was also positively associated with offspring percent lean mass (β=0.11 SD/SD, P=.006), but not total lean mass (β=0.06 SD/SD, P=.15). However, this association did not persist after adjustment for confounding factors (β=0.09 SD/SD, P=.11).
CONCLUSIONS: This observational study suggests that intrauterine exposure to 25(OH)D during late pregnancy might influence offspring muscle development through an effect primarily on muscle strength rather than on muscle mass.
Authors:
Nicholas C Harvey; Rebecca J Moon; Avan Aihie Sayer; Georgia Ntani; Justin H Davies; M Kassim Javaid; Sian M Robinson; Keith M Godfrey; Hazel M Inskip; Cyrus Cooper;
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-12-20
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  99     ISSN:  1945-7197     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  2014 Jan 
Date Detail:
Created Date:  2014-01-03     Completed Date:  2014-03-12     Revised Date:  2014-07-01    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  330-7     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Child, Preschool
Data Collection
Female
Great Britain / epidemiology
Hand Strength / physiology
Humans
Infant, Newborn
Maternal Nutritional Physiological Phenomena*
Mothers
Muscle Development / physiology*
Muscle Strength / physiology
Nutritional Status / physiology*
Pregnancy
Pregnancy Complications / epidemiology
Prenatal Exposure Delayed Effects / blood,  epidemiology
Vitamin D / blood*
Vitamin D Deficiency / complications,  epidemiology
Young Adult
Grant Support
ID/Acronym/Agency:
17702//Arthritis Research UK; MC_U147574218//Medical Research Council; MC_U147585819//Medical Research Council; MC_UP_A620_1014//Medical Research Council; MC_UP_A620_1015//Medical Research Council; MC_UP_A620_1017//Medical Research Council; MC_UU_12011/1//Medical Research Council; MC_UU_12011/2//Medical Research Council; //Arthritis Research UK; //British Heart Foundation; //Medical Research Council
Chemical
Reg. No./Substance:
1406-16-2/Vitamin D
Investigator
Investigator/Affiliation:
P Taylor / ; M Hanson / ; J P Barker / ; R Swaminathan / ; S Wickramasinghe /
Comments/Corrections

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