Document Detail


Maternal antenatal peanut consumption and peanut and rye sensitization in the offspring at adolescence.
MedLine Citation:
PMID:  21129049     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Cite this as: A. S. Kemp, A-L Ponsonby,T. Dwyer J. A. Cochrane, A. Pezic and G. Jones, Clinical & Experimental Allergy, 2011 (41) 224-231. SUMMARY: Background There is considerable controversy whether maternal peanut ingestion during pregnancy might influence sensitization in later life. Objective To examine whether maternal peanut ingestion during pregnancy might increase sensitization in the offspring. Methods A population-based longitudinal cohort study with 16 years follow-up was conducted (N=373). Subjects were recruited at birth as part of an infant health study. Maternal antenatal peanut consumption was documented at birth and peanut and rye sensitization were determined by measurement of serum-specific IgE at age 16. Results Peanut sensitization was common (14%). In the entire cohort (n=310), there was no association between antenatal peanut ingestion and peanut sensitization (P=0.17). However, there was a strong association between antenatal peanut ingestion and decreased risk of rye sensitization and peanut sensitization in those (n=201) without a family history (FH) of asthma (Rye OR 0.30, 95% CI 0.14-0.63, P=0.001 and Peanut OR 0.18, 95% CI 0.04-0.78, P=0.02). There was an increased risk of rye sensitization in those (n=108) with a FH of asthma and antenatal peanut ingestion (Rye OR 2.69, 95% CI 1.11-6.51 P=0.03). It was considered that these sensitizations were likely to be related to the presence of IgE antibodies to cross-reacting carbohydrate epitopes common to rye and peanut allergens. Conclusions and Clinical Relevance Antenatal peanut ingestion may influence the development of IgE antibody to cross-reacting carbohydrate epitopes in later life. Genetic factors may modify this association.
Authors:
A S Kemp; A-L Ponsonby; T Dwyer; J A Cochrane; A Pezic; G Jones
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Publication Detail:
Type:  Journal Article     Date:  2010-12-03
Journal Detail:
Title:  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology     Volume:  41     ISSN:  1365-2222     ISO Abbreviation:  Clin. Exp. Allergy     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8906443     Medline TA:  Clin Exp Allergy     Country:  England    
Other Details:
Languages:  eng     Pagination:  224-31     Citation Subset:  IM    
Copyright Information:
© 2010 Blackwell Publishing Ltd.
Affiliation:
Department of Allergy and Immunology, The Children's Hospital, Westmead, NSW, Australia Discipline of Paediatrics and Child Health, The Children's Hospital at Westmead, University of Sydney, NSW, Australia Murdoch Children's Research Institute, Melbourne, Australia Menzies Research Institute, University of Tasmania, Hobart, Australia.
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