| Maternal antenatal complications and the risk of neonatal cerebral white matter damage and later cerebral palsy in children born at an extremely low gestational age. | |
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MedLine Citation:
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PMID: 19713285 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In a 2002-2004 prospective cohort study of deliveries of infants at <28 weeks at 14 US centers, the authors sought the antecedents of white matter damage evident in newborn cranial ultrasound scans (ventriculomegaly and an echolucent lesion) and of cerebral palsy diagnoses at age 2 years. Of the 1,455 infants enrolled, those whose mothers received an antenatal steroid tended to have lower risks of ventriculomegaly and an echolucent lesion than their peers (10% vs. 23%, P < 0.001 and 7% vs. 11%, P = 0.06, respectively). Risk of ventriculomegaly was increased for infants delivered because of preterm labor (adjusted odds ratio (OR) = 2.3, 95% confidence interval (CI): 1.1, 4.9), preterm premature rupture of fetal membranes (OR = 3.6, 95% CI: 1.5, 8.7), and cervical insufficiency (OR = 2.8, 95% CI: 1.4, 5.5) when compared with infants delivered because of preeclampsia. Risk of an echolucent lesion was increased for infants delivered because of preterm labor (OR = 2.7, 95% CI: 1.2, 5.7) and intrauterine growth retardation (OR = 3.3, 95% CI: 1.2, 9.4). The doubling of diparesis risk associated with preterm labor and with preterm premature rupture of fetal membranes did not achieve statistical significance, nor did the doubling of quadriparesis risk and the tripling of diparesis risk associated with cervical insufficiency. |
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Authors:
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Thomas F McElrath; Elizabeth N Allred; Kim A Boggess; Karl Kuban; T Michael O'Shea; Nigel Paneth; Alan Leviton; |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Research Support, N.I.H., Extramural Date: 2009-08-27 |
Journal Detail:
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Title: American journal of epidemiology Volume: 170 ISSN: 1476-6256 ISO Abbreviation: Am. J. Epidemiol. Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-09-23 Completed Date: 2009-10-06 Revised Date: 2013-05-31 |
Medline Journal Info:
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Nlm Unique ID: 7910653 Medline TA: Am J Epidemiol Country: United States |
Other Details:
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Languages: eng Pagination: 819-28 Citation Subset: IM |
Affiliation:
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Division of Maternal-Fetal Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA. tmcelrath@partners.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cerebral Palsy
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epidemiology* Cerebral Ventricles / abnormalities Female Fetal Growth Retardation Humans Infant, Newborn Infant, Premature* Leukomalacia, Periventricular / epidemiology*, ultrasonography Male Multivariate Analysis Obstetric Labor Complications / epidemiology Pre-Eclampsia / epidemiology Pregnancy Pregnancy Complications / epidemiology* Prospective Studies Risk United States / epidemiology Uterine Cervical Incompetence / epidemiology |
| Grant Support | |
ID/Acronym/Agency:
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K12 HD01255/HD/NICHD NIH HHS; U01 NS 400069-01/NS/NINDS NIH HHS |
| Investigator | |
Investigator/Affiliation:
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Bhavesh Shah / ; Solveg Pflueger / ; Glenn Markenson / ; Camilia R Martin / ; Jonathon L Hecht / ; Bruce Cohen / ; Linda J Van Marter / ; Harvey Kliman / ; Thomas F McElrath / ; Alan Leviton / ; Robert Insoft / ; Drucilla Roberts / ; Laura Riley / ; Cynthia Cole / ; John Fiascone / ; Ina Bhan / ; Sabrina Craigo / ; Theresa Marino / ; Francis Bednarek / ; Gamze Ayata / ; Ellen Delpapa / ; Richard Ehrenkranz / ; Miguel Reyes-Múgica / ; Eduardo Zambrano / ; Keith P Williams / ; T Michael O'Shea / ; Dennis W Ross / ; Maggie Harper / ; Stephen Engelke / ; John Christie / ; Hamid Hadi / ; Carl Bose / ; Chad Livasy / ; Kim Boggess / ; Mariel Portenga / ; Barbara Doss / ; Curtis Cook / ; Padmani Karna / ; Gabriel Chamyan / ; Steve Roth / ; Michael D Schreiber / ; Aliya Husain / ; Mahmoud Ismail / ; Daniel Batton / ; Chung-Ho Chang / ; Robert Lorenz / |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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