| Maternal anesthesia via isoflurane or ether differentially affects pre-and postnatal behavior in rat offspring. | |
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MedLine Citation:
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PMID: 17943977 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Our understanding of prenatal behavior has been significantly advanced by techniques for direct observation and manipulation of unanesthetized, behaving rodent fetuses with intact umbilical connections to the mother. These techniques involve brief administration of an inhalant anesthesic, enabling spinal transection of the rat or mouse dam, after which procedures can continue with unanesthetized dams and fetuses. Because anesthetics administered to the mother can cross the placental barrier, it is possible that fetuses are anesthetized to varying degrees. We compared in perinatal rats the effects of prenatal maternal exposure to two inhalant anesthetics: ether and isoflurane. Fewer spontaneous fetal movements and first postpartum nipple attachments were observed following maternal exposure to ether as compared to isoflurane. Neonatal breathing frequencies and oxygenation did not account for group differences in nipple attachment. Our results provide evidence that the particular inhalant anesthetic employed in prenatal manipulation studies determines frequencies of perinatal behavior. |
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Authors:
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April E Ronca; Regina A Abel; Jeffrey R Alberts |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Developmental psychobiology Volume: 49 ISSN: 0012-1630 ISO Abbreviation: Dev Psychobiol Publication Date: 2007 Nov |
Date Detail:
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Created Date: 2007-10-25 Completed Date: 2008-03-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0164074 Medline TA: Dev Psychobiol Country: United States |
Other Details:
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Languages: eng Pagination: 675-84 Citation Subset: IM |
Copyright Information:
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Copyright 2007 Wiley Periodicals, Inc. |
Affiliation:
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Department of Obstetrics & Gynecology and Neurobiology & Anatomy, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA. aronca@wfubmc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anesthesia, Obstetrical* Anesthetics, Inhalation / toxicity* Animals Animals, Newborn Behavior, Animal / drug effects* Body Temperature Regulation / drug effects Ether, Ethyl / toxicity* Female Fetal Movement / drug effects Isoflurane / toxicity* Oxygen / blood Pregnancy Prenatal Exposure Delayed Effects* Rats Rats, Sprague-Dawley Sucking Behavior / drug effects |
| Grant Support | |
ID/Acronym/Agency:
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HD50201/HD/NICHD NIH HHS; MH28355/MH/NIMH NIH HHS; MH46485/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Inhalation; 26675-46-7/Isoflurane; 60-29-7/Ether, Ethyl; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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