Document Detail


Maternal anesthesia and fetal neurodevelopment.
MedLine Citation:
PMID:  22405978     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
It is clear from animal studies that commonly used anesthetic agents affect early brain development both histologically and functionally. With human epidemiologic evidence suggesting an association between anesthesia and surgery early in life and late-onset learning disabilities, investigators have focused their attention on the subtle long-term effects of anesthesia exposure. Most obstetric anesthesia studies, however, have focused on either the teratogenic effects of anesthetic agents in the first trimester or on the neonatal status immediately after delivery. Not much attention has been paid to the human second trimester, a period of active fetal brain development typified by neurogenesis and neuronal migration. Of concern though, is that these events are easily perturbed by environmental and pharmacological influences. New research studies have raised significant questions about the fetal impact of maternal anesthesia for non-obstetric and fetal surgery. This review summarizes the major findings in the field of developmental neurotoxicity of anesthetic agents, discusses the susceptibility of the fetal brain to anesthetic effects in a trimester-specific style, and outlines the pitfalls in extrapolating animal research to humans.
Authors:
A Palanisamy
Related Documents :
2618638 - Bilateral exudative retinal detachment in pregnancy.
8159368 - Intrauterine pregnancy following endometrial ablation.
20205788 - Haemoptysis in pregnancy caused by a well-differentiated fetal adenocarcinoma: a case r...
19089778 - Pregnancy-associated colon and rectal cancer: perinatal and cancer outcomes.
3119378 - In vitro fertilization and embryo transfer: treatment-dependent versus -independent pre...
11228208 - Morphometric analysis of peri-implantation endometrium in patients having excessively h...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-7
Journal Detail:
Title:  International journal of obstetric anesthesia     Volume:  -     ISSN:  1532-3374     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9200430     Medline TA:  Int J Obstet Anesth     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Affiliation:
Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Mentally challenged patients in a forensic hospital: A feasibility study concerning the executive fu...
Next Document:  Prognostic importance of tobacco use in men receiving definitive prostate brachytherapy.