Document Detail


Maternal androgen and estrogen concentrations are not associated with blood pressure changes in uncomplicated pregnancies.
MedLine Citation:
PMID:  17035416     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Systolic blood pressure increase between the second and third trimester of pregnancy has been associated with a substantially reduced maternal breast cancer risk, and it has been suggested that elevated androgens mediate the association. Androgen and estrogen concentrations were measured in maternal serum collected in 86 uncomplicated, singleton pregnancies. Overall, there were no consistent or statistically significant patterns of association between the hormones and systolic, diastolic, or mean arterial blood pressure or blood pressure change between trimesters. Results were similar with adjustment for factors related to the hormones. These data are not consistent with the hypothesis that elevated androgen concentrations mediate the observed reduction in maternal breast cancer risk associated with increases in blood pressure over the pregnancy.
Authors:
Rebecca Troisi; Lars Vatten; Robert N Hoover; James M Roberts; Bernard F Cole; Nancy Potischman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology     Volume:  15     ISSN:  1055-9965     ISO Abbreviation:  Cancer Epidemiol. Biomarkers Prev.     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-10-12     Completed Date:  2007-06-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9200608     Medline TA:  Cancer Epidemiol Biomarkers Prev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2013-5     Citation Subset:  IM    
Affiliation:
Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Bethesda, MD 20892-7246, USA. troisir@mail.nih.gov
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MeSH Terms
Descriptor/Qualifier:
Adult
Androgens / blood*
Biological Markers / blood
Blood Pressure*
Case-Control Studies
Estrogens / blood*
Female
Humans
Parity
Pennsylvania
Pre-Eclampsia / blood,  physiopathology
Pregnancy / blood*
Pregnancy Trimesters / blood
Reference Values
Chemical
Reg. No./Substance:
0/Androgens; 0/Biological Markers; 0/Estrogens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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