Document Detail


Maternal alcohol consumption during pregnancy and semen quality in the male offspring: two decades of follow-up.
MedLine Citation:
PMID:  20587536     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Concurrent alcohol exposure has been associated with reduced fecundity, but no studies have estimated the effect of prenatal alcohol exposure on male fecundity. The aim of this study was to investigate the association between maternal alcohol consumption during pregnancy, semen quality and levels of reproductive hormones in young, adult men.
METHODS: From a Danish pregnancy cohort established in 1984-1987, 347 sons were selected for a follow-up study conducted in 2005-2006. Semen and blood samples were analyzed for conventional semen characteristics and reproductive hormones, respectively, and results were related to prospectively self-reported information on maternal alcohol consumption during pregnancy.
RESULTS: The sperm concentration decreased with increasing prenatal alcohol exposure. The adjusted mean sperm concentration among sons of mothers drinking >or=4.5 drinks per week during pregnancy was 40 (95% CI: 25-60) millions/ml. This concentration was approximately 32% lower compared with men exposed to <1.0 drink per week, who had a sperm concentration of 59 (95% CI: 44-77) millions/ml. The semen volume and the total sperm count were also associated with prenatal alcohol exposure; sons prenatally exposed to 1.0-1.5 drinks per week had the highest values. No associations were found for sperm motility, sperm morphology or any of the reproductive hormones, including testosterone.
CONCLUSIONS: These results indicate that prenatal exposure to alcohol may have a persisting adverse effect on Sertoli cells, and thereby sperm concentration. If these associations are causal they could explain some of the reported differences between populations and long-term changes in semen quality.
Authors:
C H Ramlau-Hansen; G Toft; M S Jensen; K Strandberg-Larsen; M L Hansen; J Olsen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-06-29
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  25     ISSN:  1460-2350     ISO Abbreviation:  Hum. Reprod.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-18     Completed Date:  2010-12-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  England    
Other Details:
Languages:  eng     Pagination:  2340-5     Citation Subset:  IM    
Affiliation:
Department of Occupational Medicine, Aarhus University Hospital, Norrebrogade 44, Build. 2C, DK-8000 Aarhus C, Denmark. ceciraml@rm.dk
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Alcohol Drinking / adverse effects*
Cohort Studies
Dose-Response Relationship, Drug
Female
Follow-Up Studies
Humans
Infertility, Male / blood,  epidemiology*
Male
Pregnancy
Prenatal Exposure Delayed Effects*
Risk Factors
Self Report
Semen Analysis
Sperm Count
Spermatozoa / drug effects*
Testosterone / blood
Young Adult
Chemical
Reg. No./Substance:
58-22-0/Testosterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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