| Maternal alcohol and coffee drinking, parental smoking and childhood leukaemia: a French population-based case-control study. | |
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MedLine Citation:
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PMID: 17564585 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We investigated the role of maternal alcohol and coffee drinking during pregnancy and that of parental smoking in the aetiology of childhood leukaemia. A French, population-based, case-control study was conducted, comparing 472 [407 acute lymphoblastic leukaemia (ALL) and 62 acute myeloblastic leukaemia] cases of childhood acute leukaemia (AL) and 567 population controls, frequency-matched with cases on age, gender and region of residence. Both case and control mothers filled in a comprehensive self-administered standardised questionnaire, eliciting detailed data on maternal alcohol and coffee consumption during pregnancy and parental smoking before, during and after pregnancy. Maternal alcohol consumption of more than 1 drink per day was related to ALL (OR = 2.8 [95% CI 1.8, 5.9]). While maternal coffee consumption was not significantly related to AL (OR = 1.4 [95% CI 0.9, 2.3]), highest intake of coffee (more than 3 cups per day) during pregnancy was associated with AL in children whose mothers were non-smokers (OR = 1.9 [95% CI 1.0, 3.5]). No association with parental smoking, either maternal or paternal, was observed with AL. The present results suggest a possible role of the highest consumption of alcohol by the mother during pregnancy in the aetiology of childhood AL. |
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Authors:
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Florence Menegaux; Mahaut Ripert; Denis Hémon; Jacqueline Clavel |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Paediatric and perinatal epidemiology Volume: 21 ISSN: 0269-5022 ISO Abbreviation: Paediatr Perinat Epidemiol Publication Date: 2007 Jul |
Date Detail:
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Created Date: 2007-06-13 Completed Date: 2008-02-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8709766 Medline TA: Paediatr Perinat Epidemiol Country: England |
Other Details:
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Languages: eng Pagination: 293-9 Citation Subset: IM |
Affiliation:
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INSERM, U754, IFR69, and Université Paris-Sud, UMR-S754, Villejuif, France. menegaux@vjf.inserm.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Alcohol Drinking / adverse effects* Caffeine / adverse effects* Case-Control Studies Central Nervous System Stimulants / adverse effects* Child Child, Preschool Female France / epidemiology Humans Infant Leukemia, Myeloid, Acute / epidemiology, etiology* Male Mothers Precursor Cell Lymphoblastic Leukemia-Lymphoma / epidemiology, etiology* Pregnancy Risk Factors Smoking / adverse effects* |
| Chemical | |
Reg. No./Substance:
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0/Central Nervous System Stimulants; 58-08-2/Caffeine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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