Document Detail

Maternal alcohol and adrenalectomy: asynchrony of stress response and forced swim behavior.
MedLine Citation:
PMID:  11943505     Owner:  NLM     Status:  MEDLINE    
Fetal alcohol-exposed (FAE) rats exhibit heightened hormonal and behavioral stress responses, strikingly similar to those caused by exposure to elevated maternal corticosterone (CORT). Since alcohol increases maternal CORT, this study examined the effect of maternal adrenalectomy (ADX) on the CORT stress response and forced swim test (FST) behavior of the adult FAE offspring. Maternal ADX alone dramatically enhanced the CORT stress response of the offspring of pair-fed (PF) mothers but had no effect on the exaggerated CORT response to restraint stress observed in the FAE female. In contrast, maternal ADX reversed the increased immobility of FAE offspring in the FST of depressive behavior. These findings provide original evidence that stress hyper-reactivity and depressive behavior in the FAE offspring are mediated by separate developmental mechanisms.
Jennifer L Slone; Eva E Redei
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neurotoxicology and teratology     Volume:  24     ISSN:  0892-0362     ISO Abbreviation:  Neurotoxicol Teratol     Publication Date:    2002 Mar-Apr
Date Detail:
Created Date:  2002-04-10     Completed Date:  2002-08-27     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  8709538     Medline TA:  Neurotoxicol Teratol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  173-8     Citation Subset:  IM    
Department of Psychiatry and Behavioral Sciences, Asher Center, Northwestern University Medical School, Chicago, IL 60611, USA.
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MeSH Terms
Behavior, Animal / drug effects*,  physiology
Corticosterone / metabolism*,  pharmacology
Ethanol / toxicity*
Prenatal Exposure Delayed Effects*
Rats, Sprague-Dawley
Stress, Physiological / metabolism,  physiopathology*
Swimming / physiology
Reg. No./Substance:
50-22-6/Corticosterone; 64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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