Document Detail


Maternal age, multiple birth, and extremely low birth weight infants.
MedLine Citation:
PMID:  19111322     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To compare the rates of adverse neurodevelopmental outcome or death at 18 to 22 months among extremely low birth weight (ELBW) infants born to mothers >or=4 0 years to the corresponding rates among infants of younger mothers.
STUDY DESIGN: Prospective evaluation of ELBW infants to quantify the relative risks of maternal age and multiple birth for death or adverse neurodevelopmental outcome.
RESULTS: The sample consisted of 14 671 live ELBW births divided into maternal age groups: <20, 20 to 29, 30 to 39, and >or= 40 years. Of infants born to mothers >or= 40 years, 20% were multiples. Mothers >or= 40 years had high rates of obstetric interventions and medical morbidities compared with mothers <40 years. ELBW live births of mothers >or= 40 years were 22% more likely to survive and had a 13% decreased risk of neurodevelopmental impairment or death compared with mothers <20. Multiple birth, however, was associated with a 10% greater risk of neurodevelopmental impairment or death.
CONCLUSION: Although mothers >or= 40 years had high pregnancy-related morbidities, we found no overall increased risk of the composite outcome of death or NDI. Multiple birth, however, was a predictor of all adverse outcomes examined, regardless of maternal age.
Authors:
Betty R Vohr; Jon E Tyson; Linda L Wright; Rebecca L Perritt; Lei Li; W Kenneth Poole;
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural     Date:  2008-12-25
Journal Detail:
Title:  The Journal of pediatrics     Volume:  154     ISSN:  1097-6833     ISO Abbreviation:  J. Pediatr.     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-03-27     Completed Date:  2009-04-14     Revised Date:  2014-09-24    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  498-503.e2     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Central Nervous System Diseases / epidemiology*
Developmental Disabilities / epidemiology*
Female
Humans
Infant
Infant Mortality*
Infant, Newborn
Infant, Very Low Birth Weight*
Male
Maternal Age*
Pregnancy
Pregnancy Complications / epidemiology
Pregnancy, Multiple
Prospective Studies
Regression Analysis
Risk Factors
United States / epidemiology
Grant Support
ID/Acronym/Agency:
M01 RR1032/RR/NCRR NIH HHS; M01 RR16587/RR/NCRR NIH HHS; M01 RR2172/RR/NCRR NIH HHS; M01 RR2635/RR/NCRR NIH HHS; M01 RR30/RR/NCRR NIH HHS; M01 RR39/RR/NCRR NIH HHS; M01 RR44/RR/NCRR NIH HHS; M01 RR54/RR/NCRR NIH HHS; M01 RR59/RR/NCRR NIH HHS; M01 RR6022/RR/NCRR NIH HHS; M01 RR633/RR/NCRR NIH HHS; M01 RR64/RR/NCRR NIH HHS; M01 RR70/RR/NCRR NIH HHS; M01 RR7122/RR/NCRR NIH HHS; M01 RR750/RR/NCRR NIH HHS; M01 RR80/RR/NCRR NIH HHS; M01 RR8084/RR/NCRR NIH HHS; M01 RR997/RR/NCRR NIH HHS; U01 HD19897/HD/NICHD NIH HHS; U01 HD36790/HD/NICHD NIH HHS; U10 HD027904/HD/NICHD NIH HHS; U10 HD027904-19/HD/NICHD NIH HHS; U10 HD21364/HD/NICHD NIH HHS; U10 HD21373/HD/NICHD NIH HHS; U10 HD21385/HD/NICHD NIH HHS; U10 HD21397/HD/NICHD NIH HHS; U10 HD21415/HD/NICHD NIH HHS; U10 HD27851/HD/NICHD NIH HHS; U10 HD27853/HD/NICHD NIH HHS; U10 HD27856/HD/NICHD NIH HHS; U10 HD27871/HD/NICHD NIH HHS; U10 HD27880/HD/NICHD NIH HHS; U10 HD27881/HD/NICHD NIH HHS; U10 HD27904/HD/NICHD NIH HHS; U10 HD34167/HD/NICHD NIH HHS; U10 HD34216/HD/NICHD NIH HHS; U10 HD40461/HD/NICHD NIH HHS; U10 HD40492/HD/NICHD NIH HHS; U10 HD40498/HD/NICHD NIH HHS; U10 HD40521/HD/NICHD NIH HHS; U10 HD40689/HD/NICHD NIH HHS; U10 HD42638/HD/NICHD NIH HHS
Investigator
Investigator/Affiliation:
Alan Jobe / ; William Oh / ; Abbot R Laptook / ; Rachel A Vogt / ; Angelita Hensman / ; Lucy Noel / ; Barbara Alksninis / ; Shabnam Lainwala / ; Teresa M Leach / ; Martha R Leonard / ; Kalida Mehta / ; James Moore / ; Bonnie Stephens / ; Victoria E Watson / ; Avroy A Fanaroff / ; Michele C Walsh / ; Deanne Wilson-Costello / ; Nancy S Newman / ; Bonnie S Siner / ; Harriet G Friedman / ; Eileen Stork / ; Ronald N Goldberg / ; C Michael Cotton / ; Ricki F Goldstein / ; Kathy J Auten / ; Melody B Lohmeyer / ; Kathryn Gustafson / ; Barbara J Stoll / ; Lucky Jain / ; Ira Adams-Chapman / ; Neal P Simon / ; Ellen C Hale / ; Maureen Mulligan LaRossa / ; Linda Black / ; Sheena Carter / ; Elisabeth Dinkins / ; Judson Miller / ; Irma Seabrook / ; Gloria Smikle / ; Michelle Tidwell / ; Rosemary D Higgins / ; Elizabeth M McClure / ; Joel Verter / ; Tonya Powers / ; Ann R Stark / ; Kimberly Gronsman Lee / ; Kerri Fournier / ; Stacy Dow / ; Colleen Driscoll / ; James A Lemons / ; Brenda B Poindexter / ; Anna M Dusick / ; Greg Sokol / ; Marilyn Bull / ; Darlene Kardatzke / ; Carolyn Lytle / ; Diana D Appel / ; Dianne Herron / ; Lucy Miller / ; Leslie Richard / ; Leslie Dawn Wilson / ; Lon G Bohnke / ; Greg Eaken / ; Ann Cook / ; Heike Minnich / ; Abhik Das / ; Betty Hastings / ; Carolyn Petrie Huitema / ; Elizabeth Mc-Clure / ; Kristin Zaterka-Baxter / ; Scott E Schaefer / ; Jeanette O'Donnell Auman / ; David K Stevenson / ; Krisa P Van Meurs / ; Susan R Hintz / ; M Bethany Ball / ; Marian M Adams / ; Joan M Baran / ; Lori E Bond / ; Ginger Brudos / ; Maria Elena DeAnda / ; Anne M DeBattista / ; Barry E Fleisher / ; Monica Hajdena-Dawson / ; Jean Kohn / ; Carol G Kuelper / ; Julie C Lee / ; Melinda S Proud / ; Renee P Pyle / ; Dharshi Sivakumar / ; Nicholas St John / ; Waldemar A Carlo / ; Namasivayam Ambalavanan / ; Myriam Peralta-Carcelen / ; Monica V Collins / ; Shirley S Cosby / ; Vivien Phillips / ; Kirstin J Bailey / ; Fred J Biasini / ; Stephanie A Chopko / ; Julie Preskitt / ; MaryBeth Moses / ; Kathleen Nelson / ; Richard V Rector / ; Sally Whitley / ; Neil N Finer / ; Maynard R Rasmussen / ; Yvonne E Vaucher / ; Kathy Arnell / ; Clarence Demetrio / ; Martha G Fuller / ; Chris Henderson / ; Wade Rich / ; Rene Barbieri-Welge / ; Ayala Ben-Tall / ; Elaine Ito / ; Meghan Lukasik / ; Deborah Pontillo / ; Donna Posin / ; Cheryl Runyan / ; James Wilkes / ; Edward F Donovan / ; Jean Steichen / ; Kurt Schibler / ; Kathleen Bridges / ; John Fridriksson / ; Barb Alexander / ; Cathy Grisby / ; Teresa L Gratton / ; Marcia Mersmann / ; Holly Mincey / ; Jody Shively / ; Shahnaz Duara / ; Charles R Bauer / ; Sylvia Hiriart-Fajardo / ; Ruth Everett-Thomas / ; Mary Allison / ; Carmel Azemar / ; Maria Calejo / ; Alexis N Diaz / ; Silvia M Frade Eguaras / ; Yamiley C Gideon / ; Wendy Griffin / ; Rafael Guzman / ; Kasey Hamlin-Smith / ; Elizabeth Jacque / ; Lisa Jean-Gilles / ; Ann Londono / ; Elaine O Mathews / ; Alexandra Stroerger / ; Lu-Ann Papile / ; Conra Backstrom Lacy / ; Jean Lowe / ; Ginny Laadt / ; Debra V Long / ; Dale L Phelps / ; Ronnie Guillet / ; Gary J Myers / ; Carl T D'Angio / ; Linda J Reubens / ; Diane Hust / ; Rosemary L Jensen / ; Erica Burnell / ; Julie Babish Johnson / ; Cassandra A Horihan / ; Emily Kushner / ; Joan Merzbach / ; Gina Rowan / ; Kelley Yost / ; Lauren Zwetsch / ; Kristina Mossgraber / ; Sheldon B Korones / ; Henrietta S Bada / ; Kim Yolton / ; Tina Hudson / ; Abbot R Laptook / ; Charles R Rosenfeld / ; Walid A Salhab / ; R Sue Broyles / ; Roy J Heyne / ; Ricardo D Uauy / ; Susie Madison / ; Jackie F Hickman / ; Gaynelle Hensley / ; Nancy A Miller / ; Janet S Morgan / ; Sally Adams / ; Cathy Boatman / ; Cristin Dooley / ; Alicia Guzman / ; Elizabeth Heyne / ; Cristine Lupino / ; Linda Madden / ; Kathleen A Kennedy / ; Brenda H Morris / ; Pamela J Bradt / ; Patricia W Evans / ; Terri Major-Kincade / ; Laura L Whitely / ; Esther G Akpa / ; Magda Cedillo / ; Patty A Cluff / ; Anna E Lis / ; Georgia E McDavid / ; Claudia Y Franco / ; Nora I Alaniz / ; Susan Dieterich / ; Stacey Reddoch / ; Patti L Tate / ; T Michael O'Shea / ; Robert G Dillard / ; Lisa K Washburn / ; Nancy J Peters / ; Barbara G Jackson / ; Debbie Allred / ; Korinne Chiu / ; Don Goldstein / ; Raquel Halfond / ; Cherie Heller / ; Gail Hounshell / ; Melissa Morris / ; Carol Peterson / ; Ellen Waldrep / ; Seetha Shankaran / ; Yvette Johnson / ; Athina Pappas / ; Rebecca Bara / ; Geraldine Muran / ; Deborah Kennedy / ; Laura Goldston / ; Richard A Ehrenkranz / ; Ian Gross / ; Michael D Kaplan / ; Linda Mayes / ; Patricia Gettner / ; Monica Konstantino / ; Elaine Romano / ; Pat Cervone / ; Nancy Close /
Comments/Corrections

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