Document Detail


Maternal age-dependent and sex-related changes of gestational serum alpha-fetoprotein.
MedLine Citation:
PMID:  8579774     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Maternal serum alpha-fetoprotein (MSAFP) concentration values were measured in relation to maternal age and fetal sex in the 16th to 20th gestational weeks in samples taken from 9,556 pregnancies with the outcome of live, mature and healthy infants. Our results show positive significance between MSAFP concentration and maternal age (p < 0.001); we also found significantly higher AFP values in male fetuses than in female fetuses (p < 0.001). This specificity is by all probability due to the change in the physiologic AFP concentration of the pregnant woman. Considering maternal age and the new percentile AFP values, cut-off concentration values can be corrected, thus the quality of routine AFP screening can be improved. At the same time, with the application of the above parameters, a more effective selection of pregnancies at high risk for Down syndrome can be achieved.
Authors:
M Szabó; L Veress; A Münnich; Z Papp
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Fetal diagnosis and therapy     Volume:  10     ISSN:  1015-3837     ISO Abbreviation:  Fetal. Diagn. Ther.     Publication Date:    1995 Nov-Dec
Date Detail:
Created Date:  1996-03-19     Completed Date:  1996-03-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9107463     Medline TA:  Fetal Diagn Ther     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  368-72     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, Semmelweis Medical University, Budapest, Hungary.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Analysis of Variance
Female
Fetal Diseases / blood*,  diagnosis
Humans
Male
Maternal Age*
Pregnancy / blood*
Prenatal Diagnosis
Risk Factors
Sex Factors
alpha-Fetoproteins / metabolism*
Chemical
Reg. No./Substance:
0/alpha-Fetoproteins

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