Document Detail

Maternal age and adverse pregnancy outcomes: a cohort study.
MedLine Citation:
PMID:  23630102     Owner:  NLM     Status:  Publisher    
OBJECTIVE: The aim of this study was to examine the association between maternal age and a wide range of adverse pregnancy outcomes after adjustment for confounding factors in obstetric history and maternal characteristics. METHODS: This was a retrospective study in women with singleton pregnancies attending the first routine hospital visit at 11(+0) -13(+6) weeks of gestation. Data on maternal characteristics, medical and obstetric history were collected and pregnancy outcomes ascertained. Maternal age was studied, both as a continuous and as a categorical variable. Regression analysis was performed to examine the association between maternal age and adverse pregnancy outcomes including preeclampsia (PE), gestational hypertension (GH), gestational diabetes mellitus (GDM), preterm delivery (PTD), small for gestational age (SGA), large for gestational age (LGA), miscarriage, stillbirth, elective and emergency cesarean section (CS). RESULTS: The study population included 76,158 singleton pregnancies with a live fetus at 11(+0) -13(+6) weeks. After adjusting for maternal and pregnancy potential confounding variables, advanced maternal age (defined as ≥40 years) was associated with increased risk of miscarriage [OR (95% CI): 2.32 (1.83-2.93), p < 0.001], PE [1.49 (1.22-1.82), p < 0.001], GDM [1.88 (1.55-2.29) p < 0.001], SGA [1.46 (1.27-1.69) p < 0.001] and CS [1.95 (1.77-2.14) p < 0.001], but not for stillbirth, GH, spontaneous PTD or LGA. CONCLUSION: Maternal age should be combined with other maternal characteristics and obstetric history when calculating an individualised adjusted risk for adverse pregnancy complications. Advanced maternal age is a risk factor for miscarriage, PE, SGA, GDM and CS, but not for stillbirth, GH, spontaneous PTD or LGA.
Asma Khalil; Argyro Syngelaki; Nerea Maiz; Yana Zinevich; Kypros H Nicolaides
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-4-30
Journal Detail:
Title:  Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology     Volume:  -     ISSN:  1469-0705     ISO Abbreviation:  Ultrasound Obstet Gynecol     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-4-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9108340     Medline TA:  Ultrasound Obstet Gynecol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
This article is protected by copyright. All rights reserved.
Department of Fetal Medicine, Institute for Women's Health, University College London Hospitals, London, UK.
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