| Maternal acute lymphoctic leukemia with rearrangement of the mixed lineage leukemia gene occurring during pregnancy. | |
| | |
MedLine Citation:
|
PMID: 20139053 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Acute lymphoblastic leukemia (ALL) is a relatively rare disease during pregnancy, accounting for about 15% of all cases of pregnancy-associated leukemia. Although mixed lineage leukemia gene (MLL) rearrangement is the dominant genetic aberration in infantile acute leukemia, the occurrence of MLL gene rearrangement in maternal ALL occurring during pregnancy has not been reported. Out of 31 cases of maternal leukemia diagnosed during pregnancy at our institution, 5 were ALL cases. Three of the 5 patients had MLL gene rearrangement. The data for these 5 patients are presented in this report. We believe that the association of MLL gene rearrangement with maternal leukemia is biologically plausible and this observation needs to be validated in a larger cohort of pregnancy-associated maternal leukemia cases. |
| | |
Authors:
|
Mahmoud Aljurf; Amr Nassar; Abu J Saleh; Fahed Almhareb; Hazzaa Alzahrani; Claudia Walter; Mohammad Bakr; Syed Osman Ahmed; Naeem Chaudhri |
Related Documents
:
|
11444793 - Primary hyperparathyroidism and acute pancreatitis during the third trimester of pregna... 3308573 - Acute abdomen due to placenta percreta. 9579433 - Proliferation and apoptosis of fibroblasts and smooth muscle cells in rat uterine cervi... |
Publication Detail:
|
Type: Case Reports; Journal Article |
Journal Detail:
|
Title: Hematology/oncology and stem cell therapy Volume: 2 ISSN: 1658-3876 ISO Abbreviation: Hematol Oncol Stem Cell Ther Publication Date: 2009 |
Date Detail:
|
Created Date: 2010-02-08 Completed Date: 2010-10-07 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101468532 Medline TA: Hematol Oncol Stem Cell Ther Country: Saudi Arabia |
Other Details:
|
Languages: eng Pagination: 399-402 Citation Subset: IM |
Affiliation:
|
King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Antineoplastic Combined Chemotherapy Protocols / therapeutic use Cell Lineage Chromosomes, Human, Pair 11 / genetics Chromosomes, Human, Pair 4 / genetics Combined Modality Therapy Female Gene Rearrangement* Gestational Age Humans Myeloid-Lymphoid Leukemia Protein / genetics* Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*, pathology, therapy Pregnancy Pregnancy Complications, Neoplastic* Prognosis Stem Cell Transplantation Translocation, Genetic Young Adult |
| Chemical | |
Reg. No./Substance:
|
0/MLL protein, human; 149025-06-9/Myeloid-Lymphoid Leukemia Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Validation of tissue microarray biomarker expression of breast carcinomas in Saudi women.
Next Document: Accuracy of the Fischer scoring system and the Breast Imaging Reporting and Data System in identific...