Document Detail

Maternal and Zygotic Control of Zebrafish Dorsoventral Axial Patterning.
MedLine Citation:
PMID:  21942367     Owner:  NLM     Status:  Publisher    
Vertebrate development begins with precise molecular, cellular, and morphogenetic controls to establish the basic body plan of the embryo. In zebrafish, these tightly regulated processes begin during oogenesis and proceed through gastrulation to establish and pattern the axes of the embryo. During oogenesis a maternal factor is localized to the vegetal pole of the oocyte that is a determinant of dorsal tissues. Following fertilization this vegetally-localized dorsal determinant is asymmetrically translocated in the egg and initiates formation of the dorsoventral axis. Dorsoventral axis formation and patterning is then mediated by maternal and zygotic factors acting through Wnt, BMP (bone morphogenetic protein), Nodal, and FGF (fibroblast growth factor) signaling pathways, each of which is required to establish and/or pattern the dorsoventral axis. This review addresses recent advances in our understanding of the molecular factors and mechanisms that establish and pattern the dorsoventral axis of the zebrafish embryo, including establishment of the animal-vegetal axis as it relates to formation of the dorsoventral axis. Expected final online publication date for the Annual Review of Genetics Volume 45 is November 03, 2011. Please see for revised estimates.
Yvette G Langdon; Mary C Mullins
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2010-11-8
Journal Detail:
Title:  Annual review of genetics     Volume:  -     ISSN:  1545-2948     ISO Abbreviation:  -     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2011-9-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0117605     Medline TA:  Annu Rev Genet     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104; email:
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