Document Detail

Maternal zinc supplementation reduces diarrheal morbidity in peruvian infants.
MedLine Citation:
PMID:  20227716     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To test whether zinc supplementation during pregnancy would reduce infant morbidity rates. STUDY DESIGN: A double-blind, randomized controlled trial of prenatal zinc supplementation was conducted from 1995 to 1997 in a periurban slum of Lima, Peru. Participants were randomly assigned to receive daily supplementation with zinc (15 mg zinc + 60 mg iron + 250 microg folic acid) or placebo (60 iron + 250 microg folic acid) from 10 to 24 weeks gestation until 1 month postpartum. Anthropometry was measured monthly from birth through age 12 months, and morbidity and dietary intake were measured weekly from 6 to 12 months (n = 421). RESULTS: The average percentage of observation days with diarrhea among infants prenatally treated with zinc (5.8%) was reduced compared with infants in the control group (7.7%) (P = .01). Prenatal zinc supplementation reduced the likelihood of an infant experiencing diarrheal episodes of acute diarrhea lasting longer than 7 days (OR 0.66, 95% CI 0.43, 0.99, P = .04) and mucus in the stool (OR 0.65 95% CI 0.46, 0.92, P = .01) adjusting for infant age, breastfeeding, season, and hygiene and sanitation covariates. No treatment effects on respiratory illnesses, fever, or skin conditions were detected. CONCLUSIONS: Improving prenatal zinc nutrition protected against diarrheal morbidity in infant offspring through 12 months of age.
Lora L Iannotti; Nelly Zavaleta; Zulema Le?n; Clara Huasquiche; Anuraj H Shankar; Laura E Caulfield
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2010-03-15
Journal Detail:
Title:  The Journal of pediatrics     Volume:  156     ISSN:  1097-6833     ISO Abbreviation:  J. Pediatr.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-24     Completed Date:  2010-06-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  960-4, 964.e1-2     Citation Subset:  AIM; IM    
Copyright Information:
Copyright 2010 Mosby, Inc. All rights reserved.
Institute of Public Health, George Warren Brown School of Social Work, St. Louis, MO, USA.
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MeSH Terms
Breast Feeding
Diarrhea, Infantile / prevention & control*
Dietary Supplements
Double-Blind Method
Infant, Newborn
Multivariate Analysis
Prenatal Care
Principal Component Analysis
Socioeconomic Factors
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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