Document Detail


Maternal vitamin D status: implications for the development of infantile nutritional rickets.
MedLine Citation:
PMID:  20511053     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The mother is the major source of circulating 25-hydroxyvitamin D concentration in the young infant. Maternal vitamin D status is an important factor in determining the vitamin D status of the infant and their risk of developing vitamin D deficiency and infantile nutritional rickets. There is evidence that the current supplementation recommendations, particularly for pregnant and lactating women, are inadequate to ensure vitamin D sufficiency in these groups. A widespread and concerted effort is needed to ensure daily supplementation of breastfed and other infants at high risk with vitamin D 400 IU from birth and of pregnant women in high-risk communities with 2000 IU. Future studies are required to determine the optimal doses of vitamin D supplementation in pregnancy and during lactation, and for normalizing vitamin D stores in infancy to reduce the prevalence of infantile nutritional rickets. Operational research studies are needed to understand the best methods of implementing supplementation programs and the factors that are likely to impede their success.
Authors:
Kebashni Thandrayen; John M Pettifor
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Endocrinology and metabolism clinics of North America     Volume:  39     ISSN:  1558-4410     ISO Abbreviation:  Endocrinol. Metab. Clin. North Am.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-31     Completed Date:  2010-09-14     Revised Date:  2012-06-04    
Medline Journal Info:
Nlm Unique ID:  8800104     Medline TA:  Endocrinol Metab Clin North Am     Country:  United States    
Other Details:
Languages:  eng     Pagination:  303-20, table of contents     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Inc. All rights reserved.
Affiliation:
MRC Mineral Metabolism Research Unit, Department of Pediatrics, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa.
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MeSH Terms
Descriptor/Qualifier:
Breast Feeding / epidemiology
Dietary Supplements*
Female
Humans
Infant
Infant, Newborn
Lactation
Maternal Nutritional Physiological Phenomena*
Nutritional Requirements*
Pregnancy
Rickets / diet therapy*,  epidemiology,  physiopathology*
Ultraviolet Rays
Vitamin D / therapeutic use*
Vitamin D Deficiency / diet therapy*,  epidemiology,  physiopathology*
Chemical
Reg. No./Substance:
1406-16-2/Vitamin D
Comments/Corrections
Republished in:
Rheum Dis Clin North Am. 2012 Feb;38(1):61-79   [PMID:  22525843 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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