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Maternal Vitamin D Status and Adverse Pregnancy Outcomes: A Systematic Review and Meta-Analysis.
MedLine Citation:
PMID:  23311886     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract OBJECTIVE: To estimate the associations between maternal vitamin D status and adverse pregnancy outcomes. STUDY DESIGN: We searched electronic databases of the human literature in PubMed, EMBASE and the Cochrane Library up to October, 2012 using the following keywords: 'vitamin D' and 'status' or 'deficiency' or 'insufficiency' and 'pregnancy'. A systematic review and meta-analysis were conducted on observational studies that reported the association between maternal blood vitamin D levels and adverse pregnancy outcomes including preeclampsia, gestational diabetes mellitus, preterm birth or small-for-gestational age. RESULTS: Twenty-four studies met the inclusion criteria. Women with circulating 25-hydroxyvitamin D [25(OH)D] level less than 50 nmol/l in pregnancy experienced an increased risk of preeclampsia [OR 2.09 (95%CI 1.50 -2.90)], gestational diabetes mellitus [OR1.38 (1.12-1.70)], preterm birth [OR1.58 (1.08-2.31)] and small-for-gestational age [OR 1.52 (1.08-2.15)]. CONCLUSION: Low maternal vitamin D levels in pregnancy may be associated with an increased risk of preeclampsia, gestational diabetes mellitus, preterm birth and small-for-gestational age.
Authors:
Shu-Qin Wei; Hui-Ping Qi; Zhong-Cheng Luo; William D Fraser
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-13
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  -     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Obstetrics and Gynecology, Saint-Justine Hospital, University of Montreal, Montreal, Canada;
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