Document Detail

Maternal use of acetaminophen, ibuprofen, and acetylsalicylic acid during pregnancy and risk of cryptorchidism.
MedLine Citation:
PMID:  20805751     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Cyclooxygenase (COX) inhibitors-acetaminophen, ibuprofen and acetylsalicylic acid-have endocrine-disruptive properties in the rainbow trout. In humans, aspirin blocks the androgen response to human chorionic gonadotropin (hCG), and, because hCG-stimulated androgen production in utero is crucial for normal testicular descent, exposure to COX inhibitors at vulnerable times during gestation may impair testicular descent. We examined whether prenatal exposure to acetaminophen, ibuprofen, and acetylsalicylic acid was associated with increased occurrence of cryptorchidism.
METHODS: Our study used data on 47,400 live-born singleton sons of mothers enrolled in the Danish National Birth Cohort during 1996-2002. Cryptorchidism was identified in 980 boys during childhood, of whom 565 underwent orchiopexy. The use of acetaminophen, ibuprofen, and acetylsalicylic acid during pregnancy was assessed in 3 computer-assisted telephone interviews and 1 self-administered questionnaire. We estimated adjusted hazard ratios (HRs) of cryptorchidism by Cox regression analysis.
RESULTS: Exposure to acetaminophen during both the first and second trimesters was associated with increased occurrence of cryptorchidism (HR = 1.33 [95% confidence interval = 1.00-1.77]). Exposure for more than 4 weeks within the postulated time-window of programming testicular descent (gestational weeks 8-14) was associated with a HR of 1.38 (1.05-1.83) for cryptorchidism. Exposure to ibuprofen and acetylsalicylic acid was not associated with cryptorchidism.
CONCLUSION: Maternal intake of acetaminophen for more than 4 weeks during pregnancy, especially during the first and second trimesters, may moderately increase the occurrence of cryptorchidism.
Morten Søndergaard Jensen; Cristina Rebordosa; Ane Marie Thulstrup; Gunnar Toft; Henrik Toft Sørensen; Jens Peter Bonde; Tine Brink Henriksen; Jørn Olsen
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Epidemiology (Cambridge, Mass.)     Volume:  21     ISSN:  1531-5487     ISO Abbreviation:  Epidemiology     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-06     Completed Date:  2011-02-01     Revised Date:  2012-03-07    
Medline Journal Info:
Nlm Unique ID:  9009644     Medline TA:  Epidemiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  779-85     Citation Subset:  IM    
Perinatal Epidemiology Research Unit, Departments of Obstetrics and Pediatrics, Aarhus University Hospital, Skejby, Denmark.
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MeSH Terms
Acetaminophen / adverse effects*
Aspirin / adverse effects*
Cryptorchidism / chemically induced*,  epidemiology
Cyclooxygenase Inhibitors / adverse effects*
Denmark / epidemiology
Ibuprofen / adverse effects*
Maternal Exposure
Reg. No./Substance:
0/Cyclooxygenase Inhibitors; 103-90-2/Acetaminophen; 15687-27-1/Ibuprofen; 50-78-2/Aspirin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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