| Maternal thyroid function during early pregnancy and cognitive functioning in early childhood: the generation R study. | |
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MedLine Citation:
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PMID: 20534757 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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CONTEXT: Thyroid hormones are essential for neurodevelopment from early pregnancy onward. Yet population-based data on the association between maternal thyroid function in early pregnancy and children's cognitive development are sparse. OBJECTIVE: Our objective was to study associations of maternal hypothyroxinemia and of early pregnancy maternal TSH and free T(4)(FT(4)) levels across the entire range with cognitive functioning in early childhood. DESIGN AND SETTING: We conducted a population-based cohort in The Netherlands. PARTICIPANTS: Participants included 3659 children and their mothers. MAIN MEASURES: In pregnant women with normal TSH levels at 13 wk gestation (SD = 1.7), mild and severe maternal hypothyroxinemia were defined as FT(4) concentrations below the 10th and 5th percentile, respectively. Children's expressive vocabulary at 18 months was reported by mothers using the MacArthur Communicative Development Inventory. At 30 months, mothers completed the Language Development Survey and the Parent Report of Children's Abilities measuring verbal and nonverbal cognitive functioning. RESULTS: Maternal TSH was not related to the cognitive outcomes. An increase in maternal FT(4) predicted a lower risk of expressive language delay at 30 months only. However, both mild and severe maternal hypothyroxinemia was associated with a higher risk of expressive language delay across all ages [odds ratio (OR) = 1.44; 95% confidence interval (CI) = 1.09-1.91; P = 0.010 and OR = 1.80; 95% CI = 1.24-2.61; P = 0.002, respectively]. Severe maternal hypothyroxinemia also predicted a higher risk of nonverbal cognitive delay (OR = 2.03; 95% CI = 1.22-3.39; P = 0.007). CONCLUSIONS: Maternal hypothyroxinemia is a risk factor for cognitive delay in early childhood. |
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Authors:
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Jens Henrichs; Jacoba J Bongers-Schokking; Jacqueline J Schenk; Akhgar Ghassabian; Henk G Schmidt; Theo J Visser; Herbert Hooijkaas; Sabine M P F de Muinck Keizer-Schrama; Albert Hofman; Vincent V W Jaddoe; Willy Visser; Eric A P Steegers; Frank C Verhulst; Yolanda B de Rijke; Henning Tiemeier |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-06-09 |
Journal Detail:
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Title: The Journal of clinical endocrinology and metabolism Volume: 95 ISSN: 1945-7197 ISO Abbreviation: J. Clin. Endocrinol. Metab. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-08 Completed Date: 2010-09-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: United States |
Other Details:
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Languages: eng Pagination: 4227-34 Citation Subset: AIM; IM |
Affiliation:
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The Generation R Study, Erasmus Medical University Center, 3000 DR Rotterdam, The Netherlands. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Child Child Development / physiology* Cognition / physiology* Cohort Studies Developmental Disabilities / blood, etiology Family Characteristics Female Humans Hypothyroidism / blood, complications, physiopathology Maternal-Fetal Relations Mothers Pregnancy Pregnancy Trimester, First / blood, physiology* Prenatal Exposure Delayed Effects / blood, physiopathology Risk Factors Thyroid Function Tests Thyroid Gland / physiology* Thyrotropin / blood |
| Chemical | |
Reg. No./Substance:
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9002-71-5/Thyrotropin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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