| Maternal thyroid function during pregnancy and behavioral problems in the offspring: the generation R study. | |
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MedLine Citation:
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PMID: 21471776 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Maternal thyroid function during pregnancy is implicated in the neurodevelopment of the offspring, yet little is known about the effect of maternal thyroid parameters on the behavior of children. We investigated the association of maternal thyroid function during the first half of pregnancy with parent-reported problem behavior of the offspring up to age of 3 y. In the Generation R study, a population-based cohort of 3736 children and their mothers, data on maternal thyroid function and child's behavior were examined. The degree of internalizing and externalizing problems in the children were assessed with the Child Behavior Checklist at ages 1½ and 3 y. Higher levels of maternal TSH during pregnancy predicted a higher externalizing scores in children at 1½ and 3 y (B = 0.22 per SD of TSH; 95% CI: 0.04, 0.40; B = 0.10 per SD for internalizing scores; 95% CI: -0.01, 0.21). Maternal free thyroxine (T4) and total T4 were not associated with internalizing or externalizing scores of children. The linear relationship with more externalizing scores was across the range of TSH; this implies that subtle impairments of maternal thyroid function may affect the child. The results suggest that thyroid function is crucial for fetal brain development, which determines problem behavior later in life. |
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Authors:
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Akhgar Ghassabian; Jacoba J Bongers-Schokking; Jens Henrichs; Vincent W V Jaddoe; Theo J Visser; Willy Visser; Sabine M P F de Muinck Keizer-Schrama; Herbert Hooijkaas; Eric A P Steegers; Albert Hofman; Frank C Verhulst; Jan van der Ende; Yolanda B de Rijke; Henning Tiemeier |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pediatric research Volume: 69 ISSN: 1530-0447 ISO Abbreviation: Pediatr. Res. Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-04-07 Completed Date: 2011-07-25 Revised Date: 2011-12-13 |
Medline Journal Info:
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Nlm Unique ID: 0100714 Medline TA: Pediatr Res Country: United States |
Other Details:
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Languages: eng Pagination: 454-9 Citation Subset: IM |
Affiliation:
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The Generation R Study, and Department of Epidemiology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Aggression Attention Checklist Chi-Square Distribution Child Behavior* Child Behavior Disorders / etiology*, metabolism, psychology Child, Preschool Emotions Female Gestational Age Humans Infant Infant Behavior* Male Netherlands Pregnancy Prenatal Exposure Delayed Effects* Prospective Studies Risk Assessment Risk Factors Thyroid Function Tests Thyroid Gland / secretion* Thyrotropin / blood, secretion* Thyroxine / blood, secretion* |
| Chemical | |
Reg. No./Substance:
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7488-70-2/Thyroxine; 9002-71-5/Thyrotropin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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