Document Detail

Maternal thyroid function during pregnancy and behavioral problems in the offspring: the generation R study.
MedLine Citation:
PMID:  21471776     Owner:  NLM     Status:  MEDLINE    
Maternal thyroid function during pregnancy is implicated in the neurodevelopment of the offspring, yet little is known about the effect of maternal thyroid parameters on the behavior of children. We investigated the association of maternal thyroid function during the first half of pregnancy with parent-reported problem behavior of the offspring up to age of 3 y. In the Generation R study, a population-based cohort of 3736 children and their mothers, data on maternal thyroid function and child's behavior were examined. The degree of internalizing and externalizing problems in the children were assessed with the Child Behavior Checklist at ages 1½ and 3 y. Higher levels of maternal TSH during pregnancy predicted a higher externalizing scores in children at 1½ and 3 y (B = 0.22 per SD of TSH; 95% CI: 0.04, 0.40; B = 0.10 per SD for internalizing scores; 95% CI: -0.01, 0.21). Maternal free thyroxine (T4) and total T4 were not associated with internalizing or externalizing scores of children. The linear relationship with more externalizing scores was across the range of TSH; this implies that subtle impairments of maternal thyroid function may affect the child. The results suggest that thyroid function is crucial for fetal brain development, which determines problem behavior later in life.
Akhgar Ghassabian; Jacoba J Bongers-Schokking; Jens Henrichs; Vincent W V Jaddoe; Theo J Visser; Willy Visser; Sabine M P F de Muinck Keizer-Schrama; Herbert Hooijkaas; Eric A P Steegers; Albert Hofman; Frank C Verhulst; Jan van der Ende; Yolanda B de Rijke; Henning Tiemeier
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric research     Volume:  69     ISSN:  1530-0447     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-04-07     Completed Date:  2011-07-25     Revised Date:  2011-12-13    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  454-9     Citation Subset:  IM    
The Generation R Study, and Department of Epidemiology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands.
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MeSH Terms
Age Factors
Chi-Square Distribution
Child Behavior*
Child Behavior Disorders / etiology*,  metabolism,  psychology
Child, Preschool
Gestational Age
Infant Behavior*
Prenatal Exposure Delayed Effects*
Prospective Studies
Risk Assessment
Risk Factors
Thyroid Function Tests
Thyroid Gland / secretion*
Thyrotropin / blood,  secretion*
Thyroxine / blood,  secretion*
Reg. No./Substance:
7488-70-2/Thyroxine; 9002-71-5/Thyrotropin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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