Document Detail


Maternal Thrombophilia and Adverse Pregnancy Outcome: A Case-Control Study.
MedLine Citation:
PMID:  25401392     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Objective: To assess the risk of adverse pregnancy outcomes in patients with acquired and/or congenital thrombophilia factors. Patients and Methods: A cohort of 130 women with a history of pregnancy loss and no successful gestation were investigated for the presence of congenital and acquired thrombophilia factors, and then compared with a control group of 130 healthy women who had had at least one successful gestation and no pregnancy loss, and were screened for congenital and acquired thrombophilia factors. Results: Acquired and congenital thrombophilia factors were found in 30 (23%) patients and in 14 (10.8%) controls (p < 0.015). The presence of ≥1 congenital thrombophilia factor was associated with pregnancy loss with an odds ratio of 2.46 (p = 0.040). Moreover, women who had had >1 early fetal loss had a 2.85-fold risk of being carriers of congenital thrombophilia factors, compared to the controls. Conclusion: Our study showed the increased risk of miscarriage in patients with congenital thrombophilia factors and >1 early fetal loss. © 2014 S. Karger AG, Basel.
Authors:
Maria Gabriella Mazzucconi; Vitaliana De Sanctis; Marco Alfò; Maria Antonietta Amendolea; Laura Conti; Cristina Santoro; Erminia Baldacci; Monica Peraino; Cesare Masala
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-11-15
Journal Detail:
Title:  Acta haematologica     Volume:  133     ISSN:  1421-9662     ISO Abbreviation:  Acta Haematol.     Publication Date:  2014 Nov 
Date Detail:
Created Date:  2014-11-17     Completed Date:  -     Revised Date:  2014-11-18    
Medline Journal Info:
Nlm Unique ID:  0141053     Medline TA:  Acta Haematol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  242-248     Citation Subset:  -    
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