Document Detail


Maternal Th1- and Th2-type reactivity to placental antigens in normal human pregnancy and unexplained recurrent spontaneous abortions.
MedLine Citation:
PMID:  10527564     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Spontaneous abortion is the most common complication of pregnancy, but the etiology of a significant proportion of abortions is still unknown. We have examined the production of Th1- and Th2-type cytokines by women with unexplained recurrent spontaneous abortion (RSA) since it appears that successful murine pregnancy occurs in a Th2-dominant situation and that Th1-type immunity is associated with pregnancy failure. We have compared maternal reactivity toward placental antigens in women with a history of successful pregnancy with that in women with a history of RSA. This was done by coculturing maternal peripheral blood mononuclear cells (PBMC) with autologous placental cells and also by stimulating maternal PBMC with antigens from a choriocarcinoma cell line of trophoblastic origin. We detected significantly greater levels of the Th2 cytokines IL-6 and IL-10 in normal pregnancy compared to unexplained RSA and significantly higher levels of the Th1 cytokine IFN-gamma in RSA compared to normal pregnancy. These results suggest that women with normal pregnancy have a higher Th2 bias, while women with a history of RSA evince a bias toward Th1-type reactivity.
Authors:
R Raghupathy; M Makhseed; F Azizieh; N Hassan; M Al-Azemi; E Al-Shamali
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cellular immunology     Volume:  196     ISSN:  0008-8749     ISO Abbreviation:  Cell. Immunol.     Publication Date:  1999 Sep 
Date Detail:
Created Date:  1999-11-17     Completed Date:  1999-11-17     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  1246405     Medline TA:  Cell Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  122-30     Citation Subset:  IM; X    
Copyright Information:
Copyright 1999 Academic Press.
Affiliation:
Department of Microbiology, Faculty of Medicine, Kuwait University.
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MeSH Terms
Descriptor/Qualifier:
Abortion, Habitual / immunology*
Adult
Antigens, Neoplasm / immunology
Choriocarcinoma / immunology,  pathology
Female
Humans
Interferon-gamma / blood
Interleukin-10 / blood
Interleukin-6 / blood
Placenta / immunology*
Pregnancy / immunology*
Pregnancy Complications, Neoplastic / immunology,  pathology
Pregnancy Trimester, First
Pregnancy Trimester, Third
Th1 Cells / immunology*
Th2 Cells / immunology*
Trophoblasts / immunology
Tumor Cells, Cultured
Tumor Necrosis Factor-alpha / analysis
Uterine Neoplasms / immunology,  pathology
Chemical
Reg. No./Substance:
0/Antigens, Neoplasm; 0/Interleukin-6; 0/Tumor Necrosis Factor-alpha; 130068-27-8/Interleukin-10; 82115-62-6/Interferon-gamma

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