Document Detail

Maternal Stress during Pregnancy, ADHD Symptomatology in Children and Genotype: Gene-Environment Interaction.
MedLine Citation:
PMID:  22299010     Owner:  NLM     Status:  PubMed-not-MEDLINE    
OBJECTIVE: Case control studies suggest a relationship between maternal stress during pregnancy and childhood ADHD. However, maternal smoking, parenting style and parental psychiatric disorder are possible confounding factors. Our objective was to control for these factors by using an intra-familial design, and investigate gene-environment interactions.
METHODS: One hundred forty two children, ages 6 to 12, (71 with ADHD, and their 71 non-ADHD siblings) participated in the intra-familial study design. A larger sample of ADHD children (N=305) was genotyped for DAT1 and DRD4 to examine gene-environment interactions. Symptom severity was evaluated using the Child Behavior Checklist (CBCL) and the Conners' Global Index for Parents (CGI-P). The Kinney Medical and Gynecological Questionnaire was used to report stressful events during pregnancies.
RESULTS: LOGISTIC REGRESSION INDICATED THAT MOTHERS WERE MORE LIKELY TO HAVE EXPERIENCED HIGH STRESS DURING PREGNANCY OF THEIR ADHD CHILD COMPARED TO THAT OF THE UNAFFECTED SIBLING (OR: 6.3, p=.01). In the larger sample, DRD4 7/7 genotype was associated with increased symptom severity in the high stress pregnancy (p=.01).
CONCLUSIONS: Maternal stress during pregnancy was associated with the development of ADHD symptomatology after controlling for family history of ADHD and other environmental factors. This association could partly be mediated through the DRD4 genotype.
Natalie Grizenko; Marie-Eve Fortier; Christin Zadorozny; Geeta Thakur; Norbert Schmitz; Renaud Duval; Ridha Joober
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the Canadian Academy of Child and Adolescent Psychiatry = Journal de l'Académie canadienne de psychiatrie de l'enfant et de l'adolescent     Volume:  21     ISSN:  1719-8429     ISO Abbreviation:  J Can Acad Child Adolesc Psychiatry     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-02-02     Completed Date:  2012-08-23     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101280868     Medline TA:  J Can Acad Child Adolesc Psychiatry     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  9-15     Citation Subset:  -    
Department of Psychiatry, McGill University, Montreal, Quebec.
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