Document Detail

Maternal smoking in pregnancy and asthma in preschool children: a pooled analysis of eight birth cohorts.
MedLine Citation:
PMID:  22952297     Owner:  NLM     Status:  MEDLINE    
RATIONALE: Although epidemiological studies suggest that exposure to maternal smoking during fetal and early life increases the risk of childhood wheezing and asthma, previous studies were not able to differentiate the effects of prenatal from postnatal exposure.
OBJECTIVES: To assess the effect of exposure to maternal smoking only during pregnancy on wheeze and asthma among preschool-age children.
METHODS: A pooled analysis was performed based on individual participant data from eight European birth cohorts. Cohort-specific effects of maternal smoking during pregnancy, but not during the first year, on wheeze and asthma at 4 to 6 years of age were estimated using logistic regression and then combined using a random effects model. Adjustments were made for sex, parental education, parental asthma, birth weight, and siblings.
MEASUREMENTS AND MAIN RESULTS: Among the 21,600 children included in the analysis, 735 children (3.4%) were exposed to maternal smoking exclusively during pregnancy but not in the first year after birth. In the pooled analysis, maternal smoking only during pregnancy was associated with wheeze and asthma at 4 to 6 years of age, with adjusted odds ratios of 1.39 (95% confidence interval, 1.08-1.77) and 1.65 (95% confidence interval, 1.18-2.31), respectively. The likelihood to develop wheeze and asthma increased statistically significantly in a linear dose-dependent manner in relation to maternal daily cigarette consumption during the first trimester of pregnancy.
CONCLUSIONS: Maternal smoking during pregnancy appears to increase the risk of wheeze and asthma among children who are not exposed to maternal smoking after birth.
Åsa Neuman; Cynthia Hohmann; Nicola Orsini; Göran Pershagen; Esben Eller; Henrik Fomsgaard Kjaer; Ulrike Gehring; Raquel Granell; John Henderson; Joachim Heinrich; Susanne Lau; Mark Nieuwenhuijsen; Jordi Sunyer; Christina Tischer; Maties Torrent; Ulrich Wahn; Alet H Wijga; Magnus Wickman; Thomas Keil; Anna Bergström;
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't     Date:  2012-09-05
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  186     ISSN:  1535-4970     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-16     Completed Date:  2013-01-22     Revised Date:  2014-02-24    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1037-43     Citation Subset:  AIM; IM    
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MeSH Terms
Asthma / etiology*
Child, Preschool
Cohort Studies
Prenatal Exposure Delayed Effects*
Respiratory Sounds / etiology
Smoking / adverse effects*
Grant Support
092731//Wellcome Trust; G0401540//Medical Research Council; G0902125//Medical Research Council; G9815508//Medical Research Council
Comment In:
Am J Respir Crit Care Med. 2012 Nov 15;186(10):941-2   [PMID:  23155212 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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