Document Detail

Maternal smoking as a model for environmental epigenetic changes affecting birthweight and fetal programming.
MedLine Citation:
PMID:  23139402     Owner:  NLM     Status:  MEDLINE    
Although the association between maternal smoking and low birthweight infants has been well established, the mechanisms behind reduced fetal growth are still being elucidated. While many infants are exposed to tobacco smoke in utero, not all are born growth restricted or small for gestational age. Many hypotheses have emerged to explain the differential response to in utero maternal tobacco smoke exposure (MTSE). Studies have shown that both maternal and fetal genotypes may contribute to the discrepant outcomes. However, the contribution of epigenetic changes cannot be ignored. In this review we address two important questions regarding the effect of MTSE on the fetal epigenome. First, does exposure to maternal tobacco smoke in utero alter the fetal epigenome? Secondly, could these alterations be associated with the reduced fetal growth observed with MTSE?
Melissa A Suter; Amber M Anders; Kjersti M Aagaard
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2012-11-08
Journal Detail:
Title:  Molecular human reproduction     Volume:  19     ISSN:  1460-2407     ISO Abbreviation:  Mol. Hum. Reprod.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-14     Completed Date:  2013-05-20     Revised Date:  2014-01-10    
Medline Journal Info:
Nlm Unique ID:  9513710     Medline TA:  Mol Hum Reprod     Country:  England    
Other Details:
Languages:  eng     Pagination:  1-6     Citation Subset:  IM    
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MeSH Terms
Birth Weight / genetics
Epigenesis, Genetic*
Fetal Development / genetics
Fetal Growth Retardation / etiology*,  genetics*,  pathology
Gestational Age
Infant, Low Birth Weight
Infant, Newborn
Maternal Exposure / adverse effects*
Smoking / adverse effects*
Grant Support
DP2120OD001500-01/OD/NIH HHS; GM069234/GM/NIGMS NIH HHS; K12 GM084897/GM/NIGMS NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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