| Maternal Serum Vitamin D at 11-13 Weeks in Pregnancies Delivering Small for Gestational Age Neonates. | |
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MedLine Citation:
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PMID: 22261570 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Objectives: To determine if maternal serum levels of 25(OH)D at 11-13 weeks' gestation are altered in pregnancies that subsequently deliver small for gestational age (SGA) neonates and whether the levels are related to placental function reflected in serum concentration of pregnancy-associated plasma protein-A (PAPP-A). Methods: Serum 25(OH)D and PAPP-A were measured at 11-13 weeks in 150 singleton pregnancies that delivered SGA neonates and 1,000 appropriate for gestational age (AGA) controls. The median 25(OH)D and PAPP-A multiple of the unaffected median (MoM) in the outcome groups were compared. Results: In the SGA, the median serum 25(OH)D and PAPP-A were significantly decreased (0.78 vs. 1.00 MoM, p < 0.0001 and 0.78 vs. 1.00 MoM, p < 0.0001, respectively). The incidence of 25(OH)D levels below the 10th percentile was significantly higher in the SGA than the AGA group in Caucasian women (p = 0.002) but not in those of African racial origin (p = 0.183). There was no significant association between 25(OH)D MoM and PAPPA MoM in either the SGA or the AGA groups. Conclusion: Serum 25(OH)D levels at 11-13 weeks are decreased in pregnancies of Caucasian women that deliver SGA neonates but not in those of African racial origin. The decrease in 25(OH)D levels is unrelated to placental function. |
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Authors:
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Rebecca Ertl; Christina K H Yu; Robert Samaha; Ranjit Akolekar; Kypros H Nicolaides |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-18 |
Journal Detail:
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Title: Fetal diagnosis and therapy Volume: - ISSN: 1421-9964 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9107463 Medline TA: Fetal Diagn Ther Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 S. Karger AG, Basel. |
Affiliation:
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Harris Birthright Research Centre for Fetal Medicine, King's College Hospital, London, UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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