Document Detail


Maternal Serum Adiponectin at 11-13 Weeks of Gestation in Pregnancies Delivering Small for Gestation Neonates.
MedLine Citation:
PMID:  21293105     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Objective: To investigate whether maternal serum levels of adiponectin in the first trimester are altered in pregnancies that subsequently deliver small for gestational age (SGA) neonates. Methods: Maternal serum adiponectin and pregnancy-associated plasma protein A (PAPP-A) were measured at 11-13 weeks' gestation in 50 singleton normotensive pregnancies that delivered SGA neonates and 300 non-SGA controls. The median adiponectin and PAPP-A levels in the SGA and non-SGA groups, expressed as multiple of the unaffected median (MoM), were compared. Results: The distribution of serum adiponectin was made gaussian by square root (sqrt) transformation. Regression analysis in the non-SGA group demonstrated that for sqrt adiponectin a significant independent contribution was provided by maternal age, weight, smoking status, African and South-Asian racial origin. Each value in the SGA and non-SGA group was then converted into a multiple of the non-SGA median (MoM) after adjustment for maternal characteristics. In the SGA group, compared to the non-SGA controls, median maternal serum PAPP-A was decreased (0.79, interquartile range [IQR] 0.54-1.06 MoM vs. 1.00, IQR 0.71-1.39 MoM) but adiponectin MoM was not significantly different (0.89, IQR 0.65-1.31 MoM vs. 1.02, IQR 0.70-1.29 MoM). Conclusion: Maternal serum adiponectin is not a useful biochemical marker for early prediction of SGA.
Authors:
Surabhi Nanda; Ranjit Akolekar; Danielle Sodre; Eirini Vaikousi; Kypros H Nicolaides
Related Documents :
18492365 - Serum progesterone concentration on day of hcg administration and ivf outcome.
7861395 - Enhanced fetal growth in sheep administered progesterone during the first three days of...
21493985 - Stillbirths at the jos university teaching hospital: incidence, risk, and etiological f...
21389085 - Management of hyperthyroidism during pregnancy and lactation.
7936525 - Inter- and intra-observer variation in the amniotic fluid index.
21988675 - Electrophoretic serum protein fraction profile during the different physiological phase...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-2-03
Journal Detail:
Title:  Fetal diagnosis and therapy     Volume:  -     ISSN:  1421-9964     ISO Abbreviation:  -     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-2-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9107463     Medline TA:  Fetal Diagn Ther     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 S. Karger AG, Basel.
Affiliation:
Harris Birthright Research Centre for Fetal Medicine, King's College Hospital, London, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Occurrence of Cleft-Palate and Alteration of Tgf-?(3) Expression and the Mechanisms Leading to Palat...
Next Document:  Zoledronic acid treatment in children with osteogenesis imperfecta.