| Maternal serum ADAM12 levels correlate with PAPP-A levels during the first trimester. | |
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MedLine Citation:
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PMID: 20197665 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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BACKGROUND: We wished to investigate the correlation between a new Down screening marker ADAM12 (a disintegrin and metalloproteinase-12) and pregnancy-associated plasma protein-A (PAPP-A) and free beta-human chorionic gonadotropin (fbeta-hCG) during the first trimester of pregnancy. METHODS: ADAM12, PAPP-A and fbeta-hCG were measured in 225 serum samples of randomly chosen pregnancies with completely normal outcome. The samples were taken between pregnancy weeks 9+0 and 12+6. RESULTS: The ADAM12 levels tended to increase with advanced gestational age and the highest levels were detected at pregnancy week 12. The ADAM12 levels correlated with PAPP-A levels. After weight correction and logarithmic transformation the multiples of median (MoM) of ADAM12 still correlated with the MoMs of PAPP-A and also with the MoMs of fbeta-hCG. Smokers had lower ADAM12 levels than non-smokers. CONCLUSION: The secretion of ADAM12 seems to resemble the secretion of PAPP-A in the end of the first trimester. Accordingly ADAM12 appears not to be a separate marker independent of PAPP-A. It remains to be assessed whether adding ADAM12 in Down screening risk calculation will reduce the false positive rate during the first trimester of pregnancy. |
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Authors:
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Yrtti Valinen; Sini Peuhkurinen; Ilkka Y Järvelä; Päivi Laitinen; Markku Ryynanen |
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Publication Detail:
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Type: Journal Article Date: 2010-02-27 |
Journal Detail:
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Title: Gynecologic and obstetric investigation Volume: 70 ISSN: 1423-002X ISO Abbreviation: Gynecol. Obstet. Invest. Publication Date: 2010 |
Date Detail:
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Created Date: 2010-07-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7900587 Medline TA: Gynecol Obstet Invest Country: Switzerland |
Other Details:
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Languages: eng Pagination: 60-3 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010 S. Karger AG, Basel. |
Affiliation:
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Department of Obstetrics and Gynecology, Oulu University Hospital, Oulu, Finland. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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