| Maternal renal interlobar vein impedance index is higher in early- than in late-onset pre-eclampsia. | |
| | |
MedLine Citation:
|
PMID: 20178114 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVES: To test the hypothesis that Doppler characteristics of maternal renal interlobar veins (RIV) are different between pregnancies affected by early-onset pre-eclampsia (EP) and those affected by late-onset pre-eclampsia (LP). METHODS: A gestational age of 34 weeks was considered to differentiate EP from LP. All women had a renal duplex scan according to a standard protocol, with known intraobserver correlation coefficient (0.88). Maximum (Vmax) and minimum (Vmin) RIV velocities were measured on two occasions (between 28 and 32 and between 34 and 37 weeks) in 18 women with uncomplicated pregnancy (UP). In women with EP (n = 32) or LP (n = 41), these variables were measured once, within 3 days following hospital admission. Delta velocity (DeltaV) was calculated as Vmax - Vmin and the RIV impedance index (RIVI) was calculated as DeltaV/Vmax. Data on neonatal outcome and maternal renal function were obtained for UP and those with EP and LP, and group-specific means +/- SD were calculated and compared. RESULTS: Compared with UP, the RIVI of both left and right kidneys was higher in those with EP (0.49 +/- 0.13 vs. 0.36 +/- 0.04, P = 0.0001, and 0.46 +/- 0.15 vs. 0.33 +/- 0.04, P = 0.0008) and in those with LP (0.41 +/- 0.07 vs. 0.37 +/- 0.06, P = 0.04, and 0.38 +/- 0.12 vs. 0.30 +/- 0.05, P = 0.009). RIVI was higher in pregnancies with EP than in those with LP (P < or = 0.01), and this difference was associated with lower median birth-weight percentiles (22.5 (interquartile range (IQR), 15-35) vs. 40.0 (IQR, 12-55), P = 0.01), higher maternal serum uric acid concentrations (419 +/- 84 vs. 374 +/- 85 micromol/L, P = 0.03) and higher proteinuria (4131 +/- 3885 vs. 1190 +/- 1133 mg/24 h, P < 0.0001). CONCLUSION: Maternal vascular maladaption in pre-eclampsia is associated with abnormal Doppler findings in the venous compartment. RIVI is higher in EP than in LP pregnancies and this is associated with lower birth-weight percentiles and higher proteinuria. |
| | |
Authors:
|
W Gyselaers; T Mesens; K Tomsin; G Molenberghs; L Peeters |
Related Documents
:
|
8070604 - The effect of clinical chorioamnionitis on cord blood gas at term. 16009644 - Prolonged morphine exposure in utero causes fetal and placental vasoconstriction: a cas... 18279824 - Serial hemodynamic measurement in normal pregnancy, preeclampsia, and intrauterine grow... 15219884 - Aging blunts remodeling of the uterine artery during murine pregnancy. 15266954 - Mid latency and slow vertex responses during pregnancy. 9619344 - Adolescent contraception. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology Volume: 36 ISSN: 1469-0705 ISO Abbreviation: Ultrasound Obstet Gynecol Publication Date: 2010 Jul |
Date Detail:
|
Created Date: 2010-07-01 Completed Date: 2010-12-17 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9108340 Medline TA: Ultrasound Obstet Gynecol Country: England |
Other Details:
|
Languages: eng Pagination: 69-75 Citation Subset: IM |
Copyright Information:
|
Copyright 2010 ISUOG. Published by John Wiley & Sons, Ltd. |
Affiliation:
|
Department of Obstetrics & Gynecology, Ziekenhuis Oost Limburg, Genk, Belgium. wilfried.gyselaers@zol.be |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Female Gestational Age Humans Kidney / blood supply, ultrasonography* Pre-Eclampsia / physiopathology, ultrasonography* Pregnancy Renal Circulation / physiology Renal Veins / physiopathology, ultrasonography* Time Factors Ultrasonography, Doppler, Color Ultrasonography, Prenatal |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Lung tissue perfusion in congenital diaphragmatic hernia and association with the lung to head ratio...
Next Document: Middle versus anterior cerebral artery Doppler for the prediction of perinatal outcome and neonatal ...