Document Detail

Maternal protein restriction leads to hyperresponsiveness to stress and salt-sensitive hypertension in male offspring.
MedLine Citation:
PMID:  20200128     Owner:  NLM     Status:  MEDLINE    
Low birth weight humans often exhibit hypertension during adulthood. Studying the offspring of rat dams fed a maternal low-protein diet is one model frequently used to study the mechanisms of low birth weight-related hypertension. It remains unclear whether this model replicates key clinical findings of hypertension and increased blood pressure responsiveness to stress or high-salt diet. We measured blood pressure via radiotelemetry in 13-wk-old male offspring of maternal normal- and low-protein dams. Neither group exhibited hypertension at baseline; however, 1 h of restraint was accompanied by a significantly greater blood pressure response in low-protein compared with normal-protein offspring. To enhance the effect of a high-salt diet on blood pressure, normal- and low-protein offspring underwent right uninephrectomy, while controls underwent sham surgery. After 5 weeks on a high-salt diet (4% NaCl), mean arterial pressure in the Low-Protein+Sham offspring was elevated by 6 +/- 2 mmHg (P < 0.05 vs. baseline), while it remained unchanged in the normal-protein offspring. In the two uninephrectomized groups, blood pressure increased further, but was of similar magnitude. Glomerular filtration rate in the low-protein uninephrectomized offspring was 50% less than that in normal-protein offspring with intact kidneys. These data indicate that, while male low-protein offspring are not hypertensive during young adulthood, their blood pressure is hyperresponsive to restraint stress and is salt sensitive, and their glomerular filtration rate is more sensitive to hypertension-causing insults. Collectively, these may predispose for the development of hypertension later in life.
Robert A Augustyniak; Karan Singh; Daniel Zeldes; Melissa Singh; Noreen F Rossi
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-03-03
Journal Detail:
Title:  American journal of physiology. Regulatory, integrative and comparative physiology     Volume:  298     ISSN:  1522-1490     ISO Abbreviation:  Am. J. Physiol. Regul. Integr. Comp. Physiol.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-08-17     Completed Date:  2010-09-08     Revised Date:  2011-07-28    
Medline Journal Info:
Nlm Unique ID:  100901230     Medline TA:  Am J Physiol Regul Integr Comp Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  R1375-82     Citation Subset:  IM    
Department of Medicine, Wayne State University, Detroit, MI, USA.
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MeSH Terms
Birth Weight / physiology
Blood Pressure / physiology
Body Weight / physiology
Diet, Protein-Restricted
Glomerular Filtration Rate / physiology
Heart Rate / physiology
Hypertension, Renal / chemically induced,  etiology,  physiopathology*
Kidney / anatomy & histology,  growth & development,  physiology
Litter Size / physiology
Malnutrition / complications,  physiopathology*
Nephrons / physiopathology
Organ Size / physiology
Pregnancy Complications / physiopathology*
Prenatal Exposure Delayed Effects / physiopathology*
Rats, Wistar
Restraint, Physical
Sodium Chloride, Dietary / pharmacology*
Stress, Physiological / physiology*
Grant Support
Reg. No./Substance:
0/Sodium Chloride, Dietary

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