| Maternal protein restriction leads to hyperresponsiveness to stress and salt-sensitive hypertension in male offspring. | |
| | |
MedLine Citation:
|
PMID: 20200128 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Low birth weight humans often exhibit hypertension during adulthood. Studying the offspring of rat dams fed a maternal low-protein diet is one model frequently used to study the mechanisms of low birth weight-related hypertension. It remains unclear whether this model replicates key clinical findings of hypertension and increased blood pressure responsiveness to stress or high-salt diet. We measured blood pressure via radiotelemetry in 13-wk-old male offspring of maternal normal- and low-protein dams. Neither group exhibited hypertension at baseline; however, 1 h of restraint was accompanied by a significantly greater blood pressure response in low-protein compared with normal-protein offspring. To enhance the effect of a high-salt diet on blood pressure, normal- and low-protein offspring underwent right uninephrectomy, while controls underwent sham surgery. After 5 weeks on a high-salt diet (4% NaCl), mean arterial pressure in the Low-Protein+Sham offspring was elevated by 6 +/- 2 mmHg (P < 0.05 vs. baseline), while it remained unchanged in the normal-protein offspring. In the two uninephrectomized groups, blood pressure increased further, but was of similar magnitude. Glomerular filtration rate in the low-protein uninephrectomized offspring was 50% less than that in normal-protein offspring with intact kidneys. These data indicate that, while male low-protein offspring are not hypertensive during young adulthood, their blood pressure is hyperresponsive to restraint stress and is salt sensitive, and their glomerular filtration rate is more sensitive to hypertension-causing insults. Collectively, these may predispose for the development of hypertension later in life. |
| | |
Authors:
|
Robert A Augustyniak; Karan Singh; Daniel Zeldes; Melissa Singh; Noreen F Rossi |
Related Documents
:
|
7235028 - Cardiovascular and body fluid changes after aortic baroreceptor deafferentation. 18531928 - Modified amplitude and strouhal number scaling for correction of turbulent wall pressur... 20331808 - Unpleasant truths about salt restriction. 9144258 - Congestive heart failure in rats is associated with increased expression and targeting ... 7347898 - The effect of haemodilution on arterial blood pressure, central venous pressure, intrac... 16401238 - Changes in electroencephalographic activities following pressure stimulation in humans. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-03-03 |
Journal Detail:
|
Title: American journal of physiology. Regulatory, integrative and comparative physiology Volume: 298 ISSN: 1522-1490 ISO Abbreviation: Am. J. Physiol. Regul. Integr. Comp. Physiol. Publication Date: 2010 May |
Date Detail:
|
Created Date: 2010-08-17 Completed Date: 2010-09-08 Revised Date: 2011-07-28 |
Medline Journal Info:
|
Nlm Unique ID: 100901230 Medline TA: Am J Physiol Regul Integr Comp Physiol Country: United States |
Other Details:
|
Languages: eng Pagination: R1375-82 Citation Subset: IM |
Affiliation:
|
Department of Medicine, Wayne State University, Detroit, MI, USA. augustyn@oakland.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Birth Weight / physiology Blood Pressure / physiology Body Weight / physiology Diet, Protein-Restricted Female Glomerular Filtration Rate / physiology Heart Rate / physiology Hypertension, Renal / chemically induced, etiology, physiopathology* Kidney / anatomy & histology, growth & development, physiology Litter Size / physiology Male Malnutrition / complications, physiopathology* Nephrons / physiopathology Organ Size / physiology Pregnancy Pregnancy Complications / physiopathology* Prenatal Exposure Delayed Effects / physiopathology* Rats Rats, Wistar Restraint, Physical Sodium Chloride, Dietary / pharmacology* Stress, Physiological / physiology* |
| Grant Support | |
ID/Acronym/Agency:
|
HL-079102/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Sodium Chloride, Dietary |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Intermittent access to sucrose increases sucrose-licking activity and attenuates restraint stress-in...
Next Document: Inhibition of VEGF-NO dependent angiogenesis does not impair liver regeneration.