Document Detail


Maternal plasma P-selectin at 11 to 13 weeks of gestation in hypertensive disorders of pregnancy.
MedLine Citation:
PMID:  20205626     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To determine if development of preeclampsia is preceded by altered maternal plasma P-selectin and if the levels are related with uterine artery pulsatility index.
METHODS: Plasma P-selectin and uterine artery pulsatility index were measured at 11-13 weeks in 121 cases that subsequently developed preeclampsia, 87 cases that developed gestational hypertension and 208 unaffected controls.
RESULTS: In the preeclampsia group the median multiple of the median in controls (MoM) P-selectin and uterine artery PI were significantly increased (1.2 MoM and 1.3 MoM). There was no significant association between P-selectin and uterine artery pulsatility index in either the preeclampsia or control group.
CONCLUSION: In pregnancies that develop preeclampsia there is evidence of platelet activation from the first trimester. However, there is no direct link between the degree of impaired placentation and platelet activation.
Authors:
Ranjit Akolekar; Alina Veduta; Ryoko Minekawa; Teodora Chelemen; Kypros H Nicolaides
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-03-08
Journal Detail:
Title:  Hypertension in pregnancy     Volume:  30     ISSN:  1525-6065     ISO Abbreviation:  Hypertens Pregnancy     Publication Date:  2011  
Date Detail:
Created Date:  2011-07-11     Completed Date:  2012-02-13     Revised Date:  2014-07-23    
Medline Journal Info:
Nlm Unique ID:  9421297     Medline TA:  Hypertens Pregnancy     Country:  England    
Other Details:
Languages:  eng     Pagination:  311-21     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Female
Humans
Hypertension, Pregnancy-Induced / blood*,  physiopathology,  ultrasonography
P-Selectin / blood*
Pregnancy
Pregnancy Trimester, First / blood*
Prospective Studies
Pulsatile Flow / physiology
Uterine Artery / physiopathology,  ultrasonography
Chemical
Reg. No./Substance:
0/P-Selectin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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