Document Detail

Maternal plasma P-selectin at 11 to 13 weeks of gestation in hypertensive disorders of pregnancy.
MedLine Citation:
PMID:  20205626     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine if development of preeclampsia is preceded by altered maternal plasma P-selectin and if the levels are related with uterine artery pulsatility index.
METHODS: Plasma P-selectin and uterine artery pulsatility index were measured at 11-13 weeks in 121 cases that subsequently developed preeclampsia, 87 cases that developed gestational hypertension and 208 unaffected controls.
RESULTS: In the preeclampsia group the median multiple of the median in controls (MoM) P-selectin and uterine artery PI were significantly increased (1.2 MoM and 1.3 MoM). There was no significant association between P-selectin and uterine artery pulsatility index in either the preeclampsia or control group.
CONCLUSION: In pregnancies that develop preeclampsia there is evidence of platelet activation from the first trimester. However, there is no direct link between the degree of impaired placentation and platelet activation.
Ranjit Akolekar; Alina Veduta; Ryoko Minekawa; Teodora Chelemen; Kypros H Nicolaides
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-03-08
Journal Detail:
Title:  Hypertension in pregnancy     Volume:  30     ISSN:  1525-6065     ISO Abbreviation:  Hypertens Pregnancy     Publication Date:  2011  
Date Detail:
Created Date:  2011-07-11     Completed Date:  2012-02-13     Revised Date:  2014-07-23    
Medline Journal Info:
Nlm Unique ID:  9421297     Medline TA:  Hypertens Pregnancy     Country:  England    
Other Details:
Languages:  eng     Pagination:  311-21     Citation Subset:  IM    
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MeSH Terms
Hypertension, Pregnancy-Induced / blood*,  physiopathology,  ultrasonography
P-Selectin / blood*
Pregnancy Trimester, First / blood*
Prospective Studies
Pulsatile Flow / physiology
Uterine Artery / physiopathology,  ultrasonography
Reg. No./Substance:

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