| Maternal Phenylketonuria (MPKU). | |
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MedLine Citation:
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PMID: 21267327 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Untreated maternal phenylketonuria (MPKU) is a major cause of microcephaly, congenital heart disease, intrauterine growth retardation and mental retardation in the offspring of mothers who have the disease. There is evidence, however, that dietary restriction of phenylalanine in the mother before conception and throughout the pregnancy will reduce the risk of these congenital anomalies in the fetus. It is important to be alert to this preventable cause of developmental retardation and congenital abnormalities in all pregnancies until the stage is reached where every woman of child-bearing age has been through the neonatal PKU-screening program. Family physicians are advised to consider prenatal or premarital screening for PKU of all female patients of child-bearing age for the next generation. |
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Authors:
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W E Schoonheyt; W B Hanley; J T Clarke; V Austin; D A Howe |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Canadian family physician Médecin de famille canadien Volume: 32 ISSN: 0008-350X ISO Abbreviation: Can Fam Physician Publication Date: 1986 Oct |
Date Detail:
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Created Date: 2011-01-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0120300 Medline TA: Can Fam Physician Country: Canada |
Other Details:
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Languages: eng Pagination: 2253-8 Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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